微粒在风湿性疾病中的作用及其作为治疗工具的潜力。
The Role of Microparticles in Rheumatic Diseases and their Potentials as Therapeutic Tools.
作者信息
Shao Wen-Hai
机构信息
Division of Immunology, Allergy and Rheumatology, University of Cincinnati, Medical Science Building, Room 7410, 231 Albert Sabin Way, Cincinnati OH 45267, USA.
出版信息
J Mol Immunol. 2016;1(1). Epub 2016 Jul 19.
Abstract
Microparticles (MPs) play important roles in intercellular communication, including adhesion, signal transduction, cell activation, and apoptosis. They possess a wide spectrum of biological effects in the immune responses. MPs could be immunotolerogenic or immunogenic depending on the contents and composition. Elevated levels of MPs have been reported in many forms for rheumatic diseases. This review focuses on the immunopathogenic and therapeutic role of MPs in rheumatic diseases.
摘要
微粒（MPs）在细胞间通讯中发挥着重要作用，包括黏附、信号转导、细胞活化和凋亡。它们在免疫反应中具有广泛的生物学效应。根据其内容物和组成，MPs可能具有免疫耐受性或免疫原性。已有多种形式的报道称风湿性疾病中MPs水平升高。本综述重点关注MPs在风湿性疾病中的免疫致病和治疗作用。
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