Morioka Tomoaki, Emoto Masanori, Imamura Satoshi, Kakutani Yoshinori, Yamazaki Yuko, Motoyama Koka, Mori Katsuhito, Fukumoto Shinya, Shioi Atsushi, Shoji Tetsuo, Inaba Masaaki
1 Department of Metabolism Endocrinology and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan.
2 Department of Nephrology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
Diab Vasc Dis Res. 2018 Jul;15(4):352-355. doi: 10.1177/1479164118774314.
Decreased plasma n-3 polyunsaturated fatty acid levels or the n-3/n-6 polyunsaturated fatty acid ratios are associated with a risk of cardiovascular events. In this cross-sectional study, we measured plasma levels of eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid and investigated the association between the plasma polyunsaturated fatty acid profile and vascular endothelial function in 396 patients with type 2 diabetes. Endothelium-dependent, flow-mediated dilatation of the brachial artery was measured using ultrasonography. Multiple regression analyses, including age, sex, body mass index, and other cardiovascular risk factors, revealed that plasma eicosapentaenoic acid levels ( β = 0.140, p = 0.008) and the eicosapentaenoic acid/arachidonic acid ratio ( β = 0.127, p = 0.019), but not plasma docosahexaenoic acid levels ( β = 0.067, p = 0.220) or the docosahexaenoic acid/arachidonic acid ratio ( β = 0.034, p = 0.559), were independently and positively associated with flow-mediated dilatation. In conclusion, plasma eicosapentaenoic acid levels and the eicosapentaenoic acid/arachidonic acid ratio are independently associated with endothelial function in patients with type 2 diabetes. This study indicates a positive association between eicosapentaenoic acid, rather than docosahexaenoic acid, and endothelial function in type 2 diabetes.
血浆n-3多不饱和脂肪酸水平降低或n-3/n-6多不饱和脂肪酸比例降低与心血管事件风险相关。在这项横断面研究中，我们测量了396例2型糖尿病患者的血浆二十碳五烯酸、二十二碳六烯酸和花生四烯酸水平，并研究了血浆多不饱和脂肪酸谱与血管内皮功能之间的关联。使用超声测量肱动脉的内皮依赖性血流介导的扩张。包括年龄、性别、体重指数和其他心血管危险因素的多元回归分析显示，血浆二十碳五烯酸水平（β = 0.140，p = 0.008）和二十碳五烯酸/花生四烯酸比例（β = 0.127，p = 0.019）与血流介导的扩张独立且呈正相关，而血浆二十二碳六烯酸水平（β = 0.067，p = 0.220）或二十二碳六烯酸/花生四烯酸比例（β = 0.034，p = 0.559）则不然。总之，血浆二十碳五烯酸水平和二十碳五烯酸/花生四烯酸比例与2型糖尿病患者的内皮功能独立相关。这项研究表明，在2型糖尿病中，二十碳五烯酸而非二十二碳六烯酸与内皮功能呈正相关。
