Helfgott Research Institute, National University of Natural Medicine, Portland, OR, USA/Department of Neurology, Oregon Health & Science University, Portland, OR, USA/OHSU-PSU School of Public Health, Portland, OR, USA.
Helfgott Research Institute, National University of Natural Medicine, Portland, OR, USA.
Mult Scler. 2019 Jul;25(8):1178-1188. doi: 10.1177/1352458518786650. Epub 2018 Jul 9.
Mindfulness training is often used as a therapeutic intervention to manage stress and enhance emotional well-being, yet trials for multiple sclerosis (MS) are limited and few have used an active control.
Assess the feasibility of mindfulness-based stress reduction (MBSR) for people with MS and evaluate the efficacy of MBSR compared to an education control.
We conducted a single-blind, randomized trial of MBSR versus education control among 62 adults with MS. Primary outcomes were measures of feasibility. Secondary outcomes included perceived stress, anxiety, depression, fatigue, pain, resilience, and the Paced Auditory Serial Addition Test, assessed at baseline, 8 weeks, and 12 months. Mean scores for secondary outcome measures were compared between groups at each time point and within groups across time by analyses of covariance or paired -tests, respectively.
Successful recruitment and retention demonstrated feasibility. Improvements in several secondary outcomes were observed among both MBSR and control groups. However, differences between the groups were not statistically significant at either 8 weeks or 12 months.
Emotional well-being improved with both MBSR and education. Spontaneous improvement cannot be ruled out as an explanation for findings and additional studies that evaluate the impact of mindfulness training to improve emotional health are warranted.
正念训练常被用作一种治疗干预手段来管理压力和增强情绪健康，但多发性硬化症 (MS) 的试验有限，且很少使用主动对照。
评估正念减压疗法 (MBSR) 对多发性硬化症患者的可行性，并评估 MBSR 与教育对照相比的疗效。
我们对 62 名多发性硬化症患者进行了一项单盲、随机的 MBSR 与教育对照试验。主要结局是评估可行性的指标。次要结局包括感知压力、焦虑、抑郁、疲劳、疼痛、韧性以及 Paced Auditory Serial Addition Test，分别在基线、8 周和 12 个月时进行评估。在每个时间点，通过协方差分析或配对检验，分别比较两组之间的次要结局测量的平均得分，以及组内跨时间的得分。
成功的招募和保留证明了可行性。MBSR 和对照组在几个次要结局上都有改善。然而，在 8 周和 12 个月时，两组之间的差异均无统计学意义。
MBSR 和教育都能改善情绪健康。不能排除自发改善是造成研究结果的原因，需要进行更多评估正念训练对改善情绪健康影响的研究。
