Tait J, Peddie B A, Bailey R R, Arnold E P, Russell G L, Bishop V A, Burry A F
Br J Urol. 1985 Oct;57(5):552-6. doi: 10.1111/j.1464-410x.1985.tb05865.x.
Thirty-one women with the recurrent urethral syndrome (abacterial cystitis) had extensive microbiological, cytological and histological investigations. A Streptococcus species was isolated from the bladder aspirate of one patient, a wall-deficient Streptococcus species from two others and both a Lactobacillus species and Ureaplasma urealyticum from another. A possible microbiological cause was therefore identified in the bladder in only 4 of the 31 patients. A Lactobacillus species was isolated from the bladder aspirate of one control subject. Lactobacilli were grown in the voided urine of the majority of patients and in seven of the eight control subjects. Chlamydia trachomatis and Herpes simplex were isolated from the cervix and the urethra of one patient. Urethral cytology was normal in all patients. Trigonitis was noted at cystoscopy in 26 of the 31 patients. Bladder biopsies showed squamous metaplasia in 15 and lymphocytic infiltration of the lamina propria in 29, giving support to an inflammatory aetiology of this enigmatic syndrome.
31名患有复发性尿道综合征（无菌性膀胱炎）的女性接受了广泛的微生物学、细胞学和组织学检查。从1例患者的膀胱吸出物中分离出一种链球菌，从另外2例患者中分离出一种细胞壁缺陷型链球菌，从另一例患者中同时分离出一种乳酸杆菌和脲原体。因此，在31例患者中，仅4例在膀胱中确定了可能的微生物学病因。从1名对照受试者的膀胱吸出物中分离出一种乳酸杆菌。大多数患者和8名对照受试者中的7名的晨尿中培养出了乳酸杆菌。从1例患者的宫颈和尿道中分离出沙眼衣原体和单纯疱疹病毒。所有患者的尿道细胞学检查均正常。31例患者中有26例在膀胱镜检查时发现膀胱三角区炎。膀胱活检显示15例有鳞状化生，29例有固有层淋巴细胞浸润，支持了这种神秘综合征的炎症病因。
