Gilad G M, Mahon B D, Finkelstein Y, Koffler B, Gilad V H
Brain Res. 1985 Nov 18;347(2):404-8. doi: 10.1016/0006-8993(85)90209-4.
The septo-hippocampal cholinergic system in rats undergoes rapid activation after acute stress. This is expressed by rapid increases both in high affinity choline uptake and newly synthesized acetylcholine release. Administration of ACTH or corticosterone at a high dose led 10 min later to changes comparable to those observed after acute stress. Choline uptake and acetylcholine release were also elevated 2 days after adrenalectomy. The effects of adrenalectomy could be attenuated by corticosterone, but not by ACTH treatment. The results demonstrate that (a) after short term stress the septo-hippocampal cholinergic system is activated secondary to activation of the pituitary-adrenocortical axis and (b) major changes in circulating corticosterone can modulate the activity of the hippocampal cholinergic synapse.
大鼠的隔-海马胆碱能系统在急性应激后会迅速激活。这表现为高亲和力胆碱摄取和新合成的乙酰胆碱释放均迅速增加。高剂量注射促肾上腺皮质激素（ACTH）或皮质酮10分钟后会导致与急性应激后观察到的变化相当的改变。肾上腺切除术后2天，胆碱摄取和乙酰胆碱释放也会升高。肾上腺切除的影响可被皮质酮减弱，但ACTH治疗则无此作用。结果表明：（a）短期应激后，隔-海马胆碱能系统继发于垂体-肾上腺皮质轴的激活而被激活；（b）循环皮质酮的主要变化可调节海马胆碱能突触的活性。
