Gilad G M, Gilad V H, Rabey J M
Life Sci. 1986 Dec 22;39(25):2387-93. doi: 10.1016/0024-3205(86)90479-0.
The effects of the dopaminergic agonist apomorphine or the antagonist sulpiride on high affinity choline uptake and newly synthesized acetylcholine release by hippocampal synaptosomal preparations, were examined in rats subjected to immobilization stress. Increased dopamine uptake by septal synaptosomal preparations was taken as evidence for increased mesoseptal dopaminergic activity in response to stress. While apomorphine treatment failed to alter choline uptake or acetylcholine release in unhandled rats, it did however prevent the stress-induced increase in these cholinergic parameters. In contrast, after treatment with sulpiride both choline uptake and acetylcholine release were increased in unhandled rats, as they were after acute stress. Acute stress of sulpiride treated rats however resulted in changes similar to those produced by administration of either sulpiride or stress separately. We conclude that the mesoseptal dopaminergic system plays an important role in modulating the activity of the septo-hippocampal cholinergic system under stress.
在遭受固定应激的大鼠中，研究了多巴胺能激动剂阿扑吗啡或拮抗剂舒必利对海马突触体标本高亲和力胆碱摄取和新合成乙酰胆碱释放的影响。隔区突触体标本中多巴胺摄取增加被视为中隔多巴胺能活性因应激而增加的证据。虽然阿扑吗啡处理未能改变未处理大鼠的胆碱摄取或乙酰胆碱释放，但它确实阻止了应激诱导的这些胆碱能参数的增加。相反，在未处理大鼠中，舒必利处理后胆碱摄取和乙酰胆碱释放均增加，急性应激后也是如此。然而，舒必利处理大鼠的急性应激导致的变化与单独给予舒必利或应激所产生的变化相似。我们得出结论，中隔多巴胺能系统在应激状态下调节隔-海马胆碱能系统的活性中起重要作用。
