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A hyperimmunoglobulin E syndrome with normal chemotaxis in vitro and defective leukotaxis in vivo.

作者信息

Weston W L, Humbert J R, August C S, Harnett J, Mass M F, Dean P B, Hagen I M

出版信息

J Allergy Clin Immunol. 1977 Feb;59(2):115-9. doi: 10.1016/0091-6749(77)90212-3.

DOI:10.1016/0091-6749(77)90212-3
PMID:299862
Abstract

A 26-yr-old male with a lifelong history of atopic dermatitis and recurrent severe staphylococcal abscesses was found to have hyperimmunoglobulinemia E. Evaluation of both the humoral and cellular aspects of chemotaxis in vitro showed both neutrophils and monocytes to be normal. However, quantitative neutrophil migration in vivo was significantly suppressed using the patient's own serum as the attractant. This defective migration in vivo was partially corrected by serum from normal donors as the attractant and also partially corrected following plasma infusion in this patient. Evaluation of quantitative leukocyte migration in vivo may be most useful in patients suspected of defects of leukocyte mobility.

摘要

相似文献

1
A hyperimmunoglobulin E syndrome with normal chemotaxis in vitro and defective leukotaxis in vivo.
J Allergy Clin Immunol. 1977 Feb;59(2):115-9. doi: 10.1016/0091-6749(77)90212-3.
2
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Defective leukocytotaxia and recurrent staphylococcal infecion: deficiency of leukocytotaxia and abnormal granulocytes associated with increase serum IgE levels in an adult with recurrent staphylococcal infection.白细胞趋化功能缺陷与复发性葡萄球菌感染：一名复发性葡萄球菌感染的成年人存在白细胞趋化功能缺陷、异常粒细胞，且血清IgE水平升高。
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引用本文的文献

1
Human hyper-IgE syndrome: singular or plural?人类高免疫球蛋白E综合征：单数还是复数？
Mamm Genome. 2018 Aug;29(7-8):603-617. doi: 10.1007/s00335-018-9767-2. Epub 2018 Aug 9.
2
The hyper-IgE syndrome.高免疫球蛋白E综合征
Clin Rev Allergy Immunol. 2001 Feb;20(1):139-54. doi: 10.1385/CRIAI:20:1:139.
3
[The Buckley syndrome: recurring, severe staphylococcal infections, eczema and hyperimmunoglobulinemia E. (author's transl)].[巴克利综合征：复发性严重葡萄球菌感染、湿疹和高免疫球蛋白E血症。（作者译）]
Infection. 1980;8 Suppl 3:248-54. doi: 10.1007/BF01639590.