Weston W L
Pediatr Clin North Am. 1977 May;24(2):395-407. doi: 10.1016/s0031-3955(16)33426-5.
Those caring for children should recognize that cutaneous findings are common in children with host defense defects. Atopic dermatitis, recurrent or persistent pyodermas, candidiasis and lupus-like syndromes, should signal the possibility of host defense deficiencies. Particularly the findings of atopic dermatitis and recurrent skin abscesses should alert the clinician to determine serum IgE levels and neutrophil chemotaxis in such patients. The triad of generalized seborrheic dermatitis, failure to thrive, and diarrhea in an infant should bring to mind Leiner disease or severe combined immunodeficiency disease.
照顾儿童的人员应认识到，皮肤表现在有宿主防御缺陷的儿童中很常见。特应性皮炎、复发性或持续性脓疱病、念珠菌病和狼疮样综合征，应提示存在宿主防御缺陷的可能性。特别是特应性皮炎和复发性皮肤脓肿的表现，应提醒临床医生测定此类患者的血清IgE水平和中性粒细胞趋化性。婴儿出现全身性脂溢性皮炎、生长发育不良和腹泻三联征时，应想到莱纳病或严重联合免疫缺陷病。
