面向生物制药生产的酵母合成生物学应用
Applications of Yeast Synthetic Biology Geared towards the Production of Biopharmaceuticals.
作者信息
Walker Roy S K, Pretorius Isak S
机构信息
Department of Molecular Sciences, Macquarie University, Sydney 2109, Australia.
Chancellery, Macquarie University, Sydney 2109, Australia.
出版信息
Genes (Basel). 2018 Jul 6;9(7):340. doi: 10.3390/genes9070340.
Engineered yeast are an important production platform for the biosynthesis of high-value compounds with medical applications. Recent years have witnessed several new developments in this area, largely spurred by advances in the field of synthetic biology and the elucidation of natural metabolic pathways. This minireview presents an overview of synthetic biology applications for the heterologous biosynthesis of biopharmaceuticals in yeast and demonstrates the power and potential of yeast cell factories by highlighting several recent examples. In addition, an outline of emerging trends in this rapidly-developing area is discussed, hinting upon the potential state-of-the-art in the years ahead.
工程酵母是用于生物合成具有医学应用价值的高价值化合物的重要生产平台。近年来，该领域出现了一些新进展，这在很大程度上得益于合成生物学领域的进步以及对天然代谢途径的阐明。本综述概述了合成生物学在酵母中异源生物合成生物制药方面的应用，并通过突出几个近期实例展示了酵母细胞工厂的能力和潜力。此外，还讨论了这个快速发展领域的新兴趋势，对未来几年可能达到的先进水平进行了展望。
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