From the Divisions of Preventive Cardiology (B.M., E.M.U.).
Heart, Lung and Vascular Institute, University of Cincinnati College of Medicine, OH (R.B.).
Hypertension. 2018 Sep;72(3):625-631. doi: 10.1161/HYPERTENSIONAHA.118.11434.
Although hypertension is identifiable in children and adolescents, there are many knowledge gaps on how to best define and manage high blood pressure in the young. SHIP-AHOY (Study of High Blood Pressure in Pediatrics: Adult Hypertension Onset in Youth) is being conducted to address these knowledge gaps. Five hundred adolescents will be recruited and will undergo ambulatory blood pressure monitoring, echocardiographic, vascular, and cognitive assessments, as well as epigenetic studies to identify mechanisms that underlie the development of hypertensive target organ damage. Details of the design and methods that will be utilized in SHIP-AHOY are presented here, as well as baseline characteristics of the first 264 study participants. The primary aim of the study is to develop a risk-based definition of hypertension in the young that will result in better understanding of the transition from blood pressure in youth to adult cardiovascular disease.
尽管儿童和青少年的高血压是可以识别的，但对于如何最好地定义和管理年轻人的高血压，仍存在许多知识空白。SHIP-AHOY（儿科高血压研究：青少年期成人高血压发病）正在进行中，以解决这些知识空白。将招募 500 名青少年，并进行动态血压监测、超声心动图、血管和认知评估，以及表观遗传学研究，以确定导致高血压靶器官损伤发展的机制。本文介绍了 SHIP-AHOY 将使用的设计和方法的详细信息，以及前 264 名研究参与者的基线特征。该研究的主要目的是制定年轻人高血压的风险定义，从而更好地理解从青少年血压到成人心血管疾病的转变。
