Savant Jonathan D, Furth Susan L, Meyers Kevin E C
Division of Nephrology, Department of Pediatrics, The Children's Hospital of Philadelphia, Pa., USA.
Division of Nephrology, Department of Pediatrics, The Children's Hospital of Philadelphia, Pa., USA ; Department of Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pa., USA.
Pulse (Basel). 2014 May;2(1-4):69-80. doi: 10.1159/000374095. Epub 2015 Feb 18.
Arterial stiffness is a natural consequence of aging, accelerated in certain chronic conditions, and predictive of cardiovascular events in adults. Emerging research suggests the importance of arterial stiffness in pediatric populations.
There are different indices of arterial stiffness. The present manuscript focuses on carotid-femoral pulse wave velocity and pulse wave analysis, although other methodologies are discussed. Also reviewed are specific measurement considerations for pediatric populations and the literature describing arterial stiffness in children with certain chronic conditions (primary hypertension, obesity, diabetes, chronic kidney disease, hypercholesterolemia, genetic syndromes involving vasculopathy, and solid organ transplant recipients).
The measurement of arterial stiffness in children is feasible and, under controlled conditions, can give accurate information about the underlying state of the arteries. This potentially adds valuable information about the functionality of the cardiovascular system in children with a variety of chronic diseases well beyond that of the brachial artery blood pressure.
动脉僵硬度是衰老的自然结果，在某些慢性疾病中会加速发展，并且可预测成年人的心血管事件。新出现的研究表明动脉僵硬度在儿科人群中也很重要。
动脉僵硬度有不同的指标。本手稿重点关注颈股脉搏波速度和脉搏波分析，尽管也讨论了其他方法。还回顾了儿科人群的具体测量注意事项，以及描述患有某些慢性疾病（原发性高血压、肥胖症、糖尿病、慢性肾病、高胆固醇血症、涉及血管病变的遗传综合征以及实体器官移植受者）儿童的动脉僵硬度的文献。
儿童动脉僵硬度的测量是可行的，并且在可控条件下，可以提供有关动脉潜在状态的准确信息。这可能会为患有各种慢性疾病的儿童的心血管系统功能提供有价值的信息，远远超出肱动脉血压所提供的信息。
