Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Giza, 12622, Egypt.
Department of Pharmacology, National Research Centre, Dokki, Giza, 12622, Egypt.
Environ Sci Pollut Res Int. 2018 Sep;25(26):26446-26460. doi: 10.1007/s11356-018-2631-9. Epub 2018 Jul 9.
This study aimed to transform the locally available lignocellulosic residual palm frond (PF) and rice straw (RS) wastes into multifunction added products like methylated cellulose and sulfated and phosphorylated hemicelluloses by simple processes. Hydrolysis with 2 N sulfuric acid was the most suitable reaction for microcrystalline cellulose production. The characteristics of the prepared products were studied to obtain the optimum reaction conditions. Palm frond hemicellulose (PFHC) recorded the highest antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans (22, 22, 26 mm), respectively, and phosphorylated palm frond hemicellulose (PPFHC) exhibited the highest potential antioxidant activity of approximately 60%, suggesting a possible correlation between the two bioactivities. Most of extracted celluloses and their derivatives had a variety of promising probiotic activities which are expected to reduce the side effects of the gastric mucosa and possibly play a role in curing the gastric ulcer. Accordingly, the determination of anti-inflammatory and gastroprotective activity results revealed that methylcellulose, sulfated and phosphorylated hemicelluloses showed anti-inflammatory and gastroprotective activities and the capability of all tested compounds to ameliorate the ethanol-induced gastric ulcer in rats' stomach. All results recommended PF and RS and their derivatives to be used as a medicinal food.
本研究旨在通过简单的工艺将当地可用的木质纤维素残余棕榈叶（PF）和稻秸（RS）废物转化为多功能添加产品，如甲基纤维素以及硫酸化和磷酸化的半纤维素。2 N 硫酸水解是最适合生产微晶纤维素的反应。研究了制备产物的特性，以获得最佳的反应条件。棕榈叶半纤维素（PFHC）对金黄色葡萄球菌、大肠杆菌和白色念珠菌的抑菌活性最高（分别为 22、22 和 26 毫米），而磷酸化棕榈叶半纤维素（PPFHC）具有最高的潜在抗氧化活性，约为 60%，表明这两种生物活性之间可能存在相关性。大多数提取的纤维素及其衍生物具有多种有前途的益生菌活性，有望减少胃黏膜的副作用，并可能在治疗胃溃疡方面发挥作用。因此，抗炎和胃保护活性结果的测定表明，甲基纤维素、硫酸化和磷酸化的半纤维素具有抗炎和胃保护活性，并且所有测试化合物都有能力改善大鼠胃中乙醇诱导的胃溃疡。所有结果都表明 PF 和 RS 及其衍生物可作为药用食品。
