Liu Qiang
Department of Urology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, China.
Front Oncol. 2022 Jan 19;11:780925. doi: 10.3389/fonc.2021.780925. eCollection 2021.
Long noncoding RNAs (LncRNAs) are transcripts of nucleic acid sequences with a length of more than 200 bp, which have only partial coding capabilities. Recent studies have shown that lncRNAs located in the nucleus or cytoplasm can be used as gene expression regulatory elements due to their important regulatory effects in a variety of biological processes. Wilms tumor (WT) is a common abdominal tumor in children whose pathogenesis remains unclear. In recent years, many specifically expressed lncRNAs have been found in WT, which affect the occurrence and development of WT. At the same time, lncRNAs may have the capacity to become novel biomarkers for the diagnosis and prognosis of WT. This article reviews related research progress on the relationship between lncRNAs and WT, to provide a new direction for clinical diagnosis and treatment of WT.
长链非编码RNA（LncRNAs）是长度超过200个碱基对的核酸序列转录本，仅具有部分编码能力。近年来的研究表明，位于细胞核或细胞质中的lncRNAs由于在多种生物学过程中具有重要的调控作用，可作为基因表达调控元件。肾母细胞瘤（WT）是儿童常见的腹部肿瘤，其发病机制尚不清楚。近年来，在WT中发现了许多特异性表达的lncRNAs，它们影响WT的发生和发展。同时，lncRNAs可能有能力成为WT诊断和预后的新型生物标志物。本文综述了lncRNAs与WT关系的相关研究进展，为WT的临床诊断和治疗提供新的方向。
