Wang Minyan, Pu Xinghui, Zhao Yunfei, Wang Panpan, Li Zexian, Zhu Chendan, Shi Zhuangzhi
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering , Nanjing University , Nanjing 210093 , China.
J Am Chem Soc. 2018 Jul 25;140(29):9061-9065. doi: 10.1021/jacs.8b04902. Epub 2018 Jul 10.
A copper-catalyzed system has been introduced for the enantioselective defluoroalkylation of linear 1-(trifluoromethyl)alkenes through C-F activation to synthesize various gem-difluoroalkenes as carbonyl mimics. For the first time, arylboronate-activated alkyl Grignard reagents were uncovered in this cross-coupling reaction. Mechanistic studies confirmed that the tetraorganoborate complexes generated in situ were the key reactive species for this transformation.
已经引入了一种铜催化体系，用于通过C-F活化对线性1-(三氟甲基)烯烃进行对映选择性脱氟烷基化反应，以合成各种作为羰基模拟物的偕二氟烯烃。首次在这种交叉偶联反应中发现了芳基硼酸酯活化的烷基格氏试剂。机理研究证实，原位生成的四有机硼酸酯配合物是这种转化的关键反应物种。
