L'Oreal Research and Innovation, 550 Jinyu Road, Shanghai, China.
L'Oreal Research and Innovation, 1 Avenue Eugene Schueller, Aulnay Sous Bois, France.
J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Sep 1;1093-1094:77-79. doi: 10.1016/j.jchromb.2018.06.048. Epub 2018 Jun 27.
4-n-butyl resorcinol (4-nBR) is a highly effective tyrosinase inhibitor, and can be used in cosmetic product for depigmentation purpose. Its efficacy correlates with 4-nBR that absorbed by skin. In this study, skin distribution of 4-nBR within either human or pig skin ex vivo was studied and compared by three independent laboratories. Good agreement was observed in each compartment considering usual inter-lab variability. This study supports the use of pig skin as an alternative source of skin when the availability of human skin is a limiting factor.
4-正丁基间苯二酚（4-nBR）是一种高效的酪氨酸酶抑制剂，可用于化妆品中达到美白的目的。其功效与被皮肤吸收的 4-nBR 相关。本研究通过三个独立实验室，对 4-nBR 在人体或猪离体皮肤中的分布进行了研究和比较。考虑到通常的实验室间变异性，每个隔室的结果都具有良好的一致性。当人体皮肤的可用性成为限制因素时，本研究支持使用猪皮作为皮肤的替代来源。
