Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, Shenyang, China; Department of Otorhinolaryngology of The First Affiliated Hospital & Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Department of Thoracic Surgery, The First Affiliated Hospital, Dalian Medical University, Dalian, China.
Biomed Pharmacother. 2018 Oct;106:665-671. doi: 10.1016/j.biopha.2018.07.005. Epub 2018 Jul 11.
Genistein, a plant isoflavone, is reported to have therapeutic potentials in multiple cancers, However, the molecular mechanism underlying promoting cell apoptosis in laryngeal cancer remains unclear. In this study, we report that miR-1469 was induced by genistein in laryngeal cancer. Elevated miR-1469 promoted cell apoptosis and inhibited Mcl1 expression. In addition, we also observed that tumor suppressor p53 was increased under genistein treatment. Elevation of p53 promoted miR-1469 expression, leading to miR-1469 increase and Mcl1 decrease. Therefore, our findings suggest that genistein can suppress laryngeal cancer cell survival through p53 -miR-1469-Mcl1pathway.
染料木黄酮是一种植物异黄酮，据报道在多种癌症中有治疗潜力。然而，其促进喉癌细胞凋亡的分子机制尚不清楚。在本研究中，我们报道染料木黄酮可诱导喉癌细胞中 miR-1469 的表达。升高的 miR-1469 可促进细胞凋亡并抑制 Mcl1 的表达。此外，我们还观察到染料木黄酮处理后肿瘤抑制因子 p53 增加。p53 的升高可促进 miR-1469 的表达，从而导致 miR-1469 的增加和 Mcl1 的减少。因此，我们的研究结果表明，染料木黄酮可以通过 p53-miR-1469-Mcl1 通路抑制喉癌细胞的存活。
