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Cardiovascular effects of antimuscarinic agents and beta3-adrenergic receptor agonist for the treatment of overactive bladder.抗毒蕈碱药物和β3-肾上腺素能受体激动剂治疗膀胱过度活动症的心血管效应。
Expert Opin Drug Saf. 2018 May;17(5):487-497. doi: 10.1080/14740338.2018.1453496. Epub 2018 Mar 20.
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Prevalence and socio-economic burden of heart failure in an aging society of South Korea.韩国老龄化社会中心力衰竭的患病率及社会经济负担
BMC Cardiovasc Disord. 2016 Nov 10;16(1):215. doi: 10.1186/s12872-016-0404-2.
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The efficacy and tolerability of mirabegron, a β3 adrenoceptor agonist, in patients with symptoms of overactive bladder.β3肾上腺素能受体激动剂米拉贝隆在膀胱过度活动症患者中的疗效和耐受性。
Ther Adv Urol. 2016 Feb;8(1):38-46. doi: 10.1177/1756287215614237.
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Do lower urinary tract symptoms predict cardiovascular diseases in older men? A systematic review and meta-analysis.老年男性下尿路症状能否预测心血管疾病?一项系统评价和荟萃分析。
World J Urol. 2015 Dec;33(12):1911-20. doi: 10.1007/s00345-015-1560-1. Epub 2015 May 14.
7
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Drugs Aging. 2014 Feb;31(2):93-101. doi: 10.1007/s40266-013-0145-1.
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Beneficial influence of carvedilol on urologic indices in patients with hypertension and benign prostatic hyperplasia: results of a randomized, crossover study.卡维地洛对高血压合并良性前列腺增生患者泌尿系统指标的有益影响:一项随机、交叉研究的结果。
Urology. 2013 Sep;82(3):660-5. doi: 10.1016/j.urology.2013.03.087.
10
Cardiovascular effects of antimuscarinic agents in overactive bladder.抗毒蕈碱药物对膀胱过度活动症的心血管影响。
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膀胱过度活动症是心力衰竭中的一种困扰症状。

Overactive Bladder is a Distress Symptom in Heart Failure.

作者信息

Son Youn-Jung, Kwon Bo Eun

机构信息

Red Cross College of Nursing, Chung-Ang University, Seoul, Korea.

Seoul Women's College of Nursing, Seoul, Korea.

出版信息

Int Neurourol J. 2018 Jun;22(2):77-82. doi: 10.5213/inj.1836120.060. Epub 2018 Jun 30.

DOI:10.5213/inj.1836120.060
PMID:29991228
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6059908/
Abstract

The prevalence of Heart failure (HF) is expected to increase worldwide with the aging population trend. The numerous symptoms of and repeated hospitalizations for HF negatively affect the patient's quality of life and increase the patient's economic burden. Up to 50% of patients with HF suffer from urinary incontinence (UI) and an overactive bladder (OAB). However, there are limited data about the relationship between UI, OAB, and HF. The association between HF and urinary symptoms may be directly attributable to worsening HF pathophysiology. A comprehensive literature review was conducted for all publications between January 2000 and November 2017 using the PubMed, Embase, and Cochrane databases. HF represents a major and growing public health problem, with an increased risk of UI and an OAB as comorbidities. Possible effects of HF on urinary problems may be mediated by the prescription of medications for symptomatic relief. Although diuretics are typically used to relieve congestion, and angiotensin-converting enzyme inhibitors and angiotensin receptor blockers improve survival, these classes of drugs have been suggested to worsen urinary symptoms in the presence of HF. Further research is required to understand the impact of UI and an OAB on the HF illness trajectory.

摘要

随着全球人口老龄化趋势,心力衰竭(HF)的患病率预计将会上升。HF的众多症状以及反复住院对患者的生活质量产生负面影响,并增加患者的经济负担。高达50%的HF患者患有尿失禁(UI)和膀胱过度活动症(OAB)。然而,关于UI、OAB与HF之间关系的数据有限。HF与泌尿系统症状之间的关联可能直接归因于HF病理生理学的恶化。使用PubMed、Embase和Cochrane数据库,对2000年1月至2017年11月期间的所有出版物进行了全面的文献综述。HF是一个日益严重的主要公共卫生问题,UI和OAB作为合并症的风险增加。HF对泌尿系统问题的可能影响可能是通过使用缓解症状的药物来介导的。尽管利尿剂通常用于缓解充血,血管紧张素转换酶抑制剂和血管紧张素受体阻滞剂可提高生存率,但有人认为这些药物类别在存在HF时会加重泌尿系统症状。需要进一步研究以了解UI和OAB对HF疾病进程的影响。