Baser Aykut, Eliaçık Sinan, Baykam Mehmet Murat, Tan Funda Uysal
Department of Urology, Hitit University School of Medicine, Corum, Turkey.
Department of Neurology, Hitit University School of Medicine, Corum, Turkey.
Int Neurourol J. 2020 Dec;24(4):375-381. doi: 10.5213/inj.2040186.093. Epub 2020 Dec 9.
The aim of this study was to investigate the clinical manifestations of overactive bladder (OAB) with migraine as a comorbidity and to shed light on possible new treatment strategies.
This study included patients aged 18 years and older who were admitted to urology and neurology outpatient clinics between March 1, 2019 and March 1, 2020 for OAB and migraine. The study questionnaire contained 3 sections: (1) questions on demographic characteristics, (2) a migraine ID test, and (3) the Overactive Bladder Inquiry Form - V8 (OAB-V8) form.
A total of 265 patients participated in the study. The average age of the participants was 39.75±11.93 years. The patients were divided into 3 groups according to the coexistence of OAB with migraine: group 1, OAB(+)/migraine(+); group 2, OAB(+)/migraine(-); and group 3, OAB(-)/migraine(+). The mean OAB-V8 score was 22.82 ±8.15 in group 1 and 25.64±7.49 in group 2. The mean OAB-V8 score of OAB patients with migraine as a comorbidity was statistically significantly lower than that of OAB patients without migraine (P=0.015). The median visual analogue scale (VAS) score was 7.11 (range, 2-10) in group 1 and 5.95 (range, 2-10) in group 3. This finding indicates that in patients with migraine, having OAB was associated with significantly higher VAS scores (P<0.001).
OAB and migraine may be comorbid conditions coexisting in a single patient. This comorbidity may lead to a lower perception of OAB symptoms in OAB patients or, conversely, to a higher perception of migraine pain. Further studies are needed to elucidate how treatments for each of these diseases can affect the other disease.
本研究旨在调查伴有偏头痛合并症的膀胱过度活动症（OAB）的临床表现，并阐明可能的新治疗策略。
本研究纳入了2019年3月1日至2020年3月1日期间因OAB和偏头痛入住泌尿外科和神经科门诊的18岁及以上患者。研究问卷包含3个部分：（1）人口统计学特征问题，（2）偏头痛识别测试，（3）膀胱过度活动症调查问卷-V8（OAB-V8）表格。
共有265名患者参与了本研究。参与者的平均年龄为39.75±11.93岁。根据OAB与偏头痛的共存情况，将患者分为3组：第1组，OAB（+）/偏头痛（+）；第2组，OAB（+）/偏头痛（-）；第3组，OAB（-）/偏头痛（+）。第1组的平均OAB-V8评分为22.82±8.15，第2组为25.64±7.49。合并偏头痛的OAB患者的平均OAB-V8评分在统计学上显著低于无偏头痛的OAB患者（P=0.015）。第1组的视觉模拟量表（VAS）评分中位数为7.11（范围2-10），第3组为5.95（范围2-10）。这一发现表明，在偏头痛患者中，患有OAB与显著更高的VAS评分相关（P<0.001）。
OAB和偏头痛可能是存在于同一患者中的合并症。这种合并症可能导致OAB患者对OAB症状的感知较低，或者相反，导致对偏头痛疼痛的感知较高。需要进一步研究以阐明针对这些疾病中每种疾病的治疗如何影响另一种疾病。
