肿瘤芽殖在头颈部鳞状细胞癌中的影响：一项荟萃分析。
Impact of tumor budding in head and neck squamous cell carcinoma: A meta-analysis.
作者信息
Zhu Yue, Liu Haichao, Xie Nan, Liu Xiqiang, Huang Hongzhang, Wang Cheng, Hou Jinsong
机构信息
Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
出版信息
Head Neck. 2019 Feb;41(2):542-550. doi: 10.1002/hed.25462. Epub 2018 Dec 14.
Tumor budding (TB) has been suggested as an adverse prognostic factor in head and neck squamous cell carcinoma (HNSCC). This meta-analysis evaluated the prognostic role of TB in HNSCC. We systematically reviewed the literatures of electronic databases and performed a meta-analysis to address the impact of TB on prognosis in HNSCC. Published data were extracted and organized. Then, pooled odds ratios for lymph node metastasis (LNM) and hazard ratios for survival were calculated by using the Mantel-Haenszel fixed effect model. The results showed that high TB was significantly associated with LNM and worse survival in patients with HNSCC. Moreover, high TB was also correlated with poor prognosis in patients with cT1-2N0 oral squamous cell carcinoma. TB is a promising prognostic factor associated with LNM and worse survival, which should be included in the routine pathological examination of HNSCC.
肿瘤芽生（TB）已被认为是头颈部鳞状细胞癌（HNSCC）的不良预后因素。本荟萃分析评估了TB在HNSCC中的预后作用。我们系统回顾了电子数据库中的文献，并进行了荟萃分析以探讨TB对HNSCC预后的影响。提取并整理已发表的数据。然后，使用Mantel-Haenszel固定效应模型计算淋巴结转移（LNM）的合并比值比和生存的风险比。结果表明，高TB与HNSCC患者的LNM及较差的生存率显著相关。此外，高TB也与cT1-2N0口腔鳞状细胞癌患者的预后不良相关。TB是一个与LNM及较差生存率相关的有前景的预后因素，应纳入HNSCC的常规病理检查中。
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