Ruckmani A, Meti Vinayak, Vijayashree R, Arunkumar R, Konda Venugopala Rao, Prabhu Lakshmipathy, Madhavi E, Devi Sobita
Department of Pharmacology, Chettinad Hospital & Research Institute, Kelambakkam, Chennai, 603103, Tamil Nadu, India.
Department of Pathology, Chettinad Hospital & Research Institute, Kelambakkam, Chennai, 603103, Tamil Nadu, India.
J Tradit Complement Med. 2017 Jul 5;8(3):377-386. doi: 10.1016/j.jtcme.2017.06.003. eCollection 2018 Jul.
one of the first recorded plants used for its seeds, is reported to have analgesic, antioxidant, anticancer, anti-obesity as well as hepato and nephro protective activities. The current study evaluated the effects of two doses (400 and 800 mg/kg) of ethanolic extract of . seeds in Freund's complete adjuvant induced arthritis in rats in comparison with diclofenac and methotrexate by the changes produced in body weight, body temperature, paw volume and spontaneous activity, hemoglobin, erythrocyte sedimentation rate, total white blood cells, red blood cells, Interleukin-6 and Tumor necrosis factor-α as well as joint changes in X-ray and histological changes in joint tissue. Unlike the untreated group, the groups treated with . showed significant decrease in paw volume, body weight, white blood cell count, erythrocyte sedimentation rate, Interleukin-6 and Tumor necrosis factor-α and an increase in body weight, spontaneous activity, hemoglobin level, and red blood cell count. Histopathological examination showed gross reduction in synovial inflammation and cartilage damage. X-ray revealed significant improvement in joint space. The effect of ethanolic extract of . was found to be equivalent to methotrexate and greater than diclofenac.
据记载，最早因其种子而被使用的植物之一具有止痛、抗氧化、抗癌、抗肥胖以及肝脏和肾脏保护活性。本研究通过观察体重、体温、爪体积和自发活动、血红蛋白、红细胞沉降率、总白细胞、红细胞、白细胞介素-6和肿瘤坏死因子-α的变化以及X射线关节变化和关节组织的组织学变化，评估了两种剂量（400和800毫克/千克）的[植物名称]种子乙醇提取物对弗氏完全佐剂诱导的大鼠关节炎的影响，与双氯芬酸和甲氨蝶呤进行比较。与未治疗组不同，用[植物名称]治疗的组爪体积、体重、白细胞计数、红细胞沉降率、白细胞介素-6和肿瘤坏死因子-α显著降低，体重、自发活动、血红蛋白水平和红细胞计数增加。组织病理学检查显示滑膜炎症和软骨损伤明显减轻。X射线显示关节间隙有显著改善。发现[植物名称]乙醇提取物的效果与甲氨蝶呤相当，且优于双氯芬酸。
