一种人类多能造血集落刺激因子对正常细胞和白血病细胞的生物学活性。
Biological activities of a human pluripotent hemopoietic colony stimulating factor on normal and leukemic cells.
作者信息
Platzer E, Welte K, Gabrilove J L, Lu L, Harris P, Mertelsmann R, Moore M A
出版信息
J Exp Med. 1985 Dec 1;162(6):1788-801. doi: 10.1084/jem.162.6.1788.
Abstract
We studied the biological effects of pluripoietin, a human pluripotent hemopoietic colony-stimulating factor (CSF) purified from the 5637 bladder carcinoma cell line. We found that this human CSF appears to be a unique hemopoietic growth factor, differing from interleukin 3 (IL-3) by virtue of its leukemia differentiating activity in mouse and man, and from mouse granulocyte CSF, which does have differentiation-inducing activity, but lacks pluripoietic activity. In addition, differences from IL-3 were observed in cross-species activity on normal and leukemic cells.
摘要
我们研究了多能素的生物学效应，多能素是一种从5637膀胱癌细胞系中纯化出来的人多能造血集落刺激因子（CSF）。我们发现，这种人CSF似乎是一种独特的造血生长因子，在人和小鼠中其白血病分化活性与白细胞介素3（IL-3）不同，与小鼠粒细胞CSF也不同，小鼠粒细胞CSF虽具有分化诱导活性，但缺乏多能造血活性。此外，在对正常细胞和白血病细胞的跨物种活性方面也观察到了与IL-3的差异。
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J Exp Med. 1985 Dec 1;162(6):1788-801. doi: 10.1084/jem.162.6.1788.
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Biochemical properties of differentiation factors for murine myelomonocytic leukemic cells in organ conditioned media--separation from colony-stimulating factors.器官条件培养基中鼠骨髓单核细胞白血病细胞分化因子的生化特性——与集落刺激因子的分离
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