Katano M, Nakamura M, Matsuo T, Iyama A, Hisatsugu T
Department of Surgery, Saga Medical School, Japan.
Surg Today. 1995;25(3):202-6. doi: 10.1007/BF00311527.
In this study, the ability of granulocyte colony-stimulating factor (G-CSF) to treat or prevent chemotherapy-induced oral mucositis in patients with advanced breast cancer was evaluated. A total of 14 patients who received intraarterial (i.a.) adriamycin (ADM) preoperatively were divided into two groups according to whether or not G-CSF was given. Thus, group A (n = 7) was given G-CSF and group B (n = 7) was not. G-CSF therapy reduced both the incidence and duration of ADM-induced oral mucositis, and a positive correlation was also seen between the incidence of mucositis and ADM-induced leukopenia (< 2,000/mm3). Group A was further divided into two subgroups according to whether G-CSF was given after or before the leukopenia had dropped below 2,000/mm3: group A-1 (n = 3) and group A-2 (n = 4), respectively. ADM-induced mucositis was observed in two of the three patients in group A-1, but in none of the four patients in group A-2. These results strongly support the idea that G-CSF can effectively treat and prevent ADM-induced oral mucositis.
在本研究中，评估了粒细胞集落刺激因子（G-CSF）治疗或预防晚期乳腺癌患者化疗引起的口腔黏膜炎的能力。共有14例术前接受动脉内（i.a.）阿霉素（ADM）治疗的患者，根据是否给予G-CSF分为两组。因此，A组（n = 7）给予G-CSF，B组（n = 7）未给予。G-CSF治疗降低了ADM引起的口腔黏膜炎的发生率和持续时间，并且黏膜炎的发生率与ADM引起的白细胞减少（<2,000/mm³）之间也存在正相关。A组根据白细胞减少降至2,000/mm³以下后还是之前给予G-CSF，进一步分为两个亚组：分别为A-1组（n = 3）和A-2组（n = 4）。A-1组的3例患者中有2例观察到ADM引起的黏膜炎，但A-2组的4例患者中均未观察到。这些结果有力地支持了G-CSF可以有效治疗和预防ADM引起的口腔黏膜炎这一观点。
