多能素α：一种由人膀胱癌细胞系5637产生的第二种人造血集落刺激因子。
Pluripoietin alpha: a second human hematopoietic colony-stimulating factor produced by the human bladder carcinoma cell line 5637.
作者信息
Gabrilove J L, Welte K, Harris P, Platzer E, Lu L, Levi E, Mertelsmann R, Moore M A
出版信息
Proc Natl Acad Sci U S A. 1986 Apr;83(8):2478-82. doi: 10.1073/pnas.83.8.2478.
Abstract
We have identified a factor constitutively produced by the human bladder carcinoma cell line 5637, which has the following capacities: to induce the differentiation of the human promyelocytic leukemic cell line HL-60; to induce the expression of chemotactic peptide receptors in leukemic cells as well as in normal peripheral blood granulocytes; to function as a chemoattractant for neutrophils as well as, under certain conditions, inhibiting their migration; to support the growth of eosinophil and granulocyte/macrophage progenitors, which is maximal when scored at day 14; and to support the growth of human mixed pluripotent progenitors and erythroid bursts from normal human bone marrow. This factor has a molecular size of 32 kDa by gel filtration and 16.5 kDa by NaDodSO4/PAGE. We have termed this factor pluripoietin alpha.
摘要
我们已经鉴定出一种由人膀胱癌细胞系5637组成性产生的因子，它具有以下能力：诱导人早幼粒细胞白血病细胞系HL-60分化；诱导白血病细胞以及正常外周血粒细胞中趋化肽受体的表达；作为嗜中性粒细胞的趋化剂，并在某些条件下抑制其迁移；支持嗜酸性粒细胞和粒细胞/巨噬细胞祖细胞的生长，在第14天评分时达到最大值；支持人混合多能祖细胞的生长以及正常人骨髓中红系爆式集落的生长。通过凝胶过滤法测得该因子的分子大小为32 kDa，通过十二烷基硫酸钠/聚丙烯酰胺凝胶电泳法测得为16.5 kDa。我们将该因子命名为多能素α。
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Pluripoietin alpha: a second human hematopoietic colony-stimulating factor produced by the human bladder carcinoma cell line 5637.多能素α：一种由人膀胱癌细胞系5637产生的第二种人造血集落刺激因子。
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J Exp Med. 1985 Dec 1;162(6):1788-801. doi: 10.1084/jem.162.6.1788.
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