用合成肽抗血清检测和定位禽成髓细胞瘤病毒的v-myb（AMV）基因产物
Detection and localization of the v-myb(AMV) gene products of avian myeloblastosis virus by a synthetic peptide antiserum.
作者信息
Wright S E, Smith D P, Wright D E
出版信息
J Gen Virol. 1985 Dec;66 ( Pt 12):2755-60. doi: 10.1099/0022-1317-66-12-2755.
PMID:2999319
Abstract
An antiserum made against a synthetic peptide from an internal region of the predicted amino acid sequence of the avian myeloblastosis virus (AMV) transforming v-myb(AMV) gene identified two products, p46v-myb(AMV) and p32v-myb(AMV), which were localized in the nucleus of AMV-transformed myeloblasts. We propose that these proteins are the in vivo products of the v-myb(AMV) gene and thus the transforming protein(s) of AMV.
摘要
一种针对禽成髓细胞瘤病毒（AMV）转化性v-myb（AMV）基因预测氨基酸序列内部区域的合成肽制备的抗血清，鉴定出两种产物，即p46v-myb（AMV）和p32v-myb（AMV），它们定位于AMV转化的成髓细胞的细胞核中。我们提出这些蛋白质是v-myb（AMV）基因的体内产物，因此是AMV的转化蛋白。
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