a Department of Ophthalmology, Emory Eye Center , Emory University School of Medicine , Atlanta , Georgia , USA.
b Emory Global Health Institute , Emory University School of Medicine , Atlanta , Georgia , USA.
Ocul Immunol Inflamm. 2018;26(7):1128-1134. doi: 10.1080/09273948.2018.1484493. Epub 2018 Jul 11.
In the wake of the international Ebola virus disease (EVD) outbreak from 2014 to 2016, thousands of EVD survivors are at-risk of ophthalmic manifestations, as well as systemic sequelae including arthralgias, abdominal pain, psychosocial stressors, and risk of viral persistence in immune-privileged organs. Ophthalmic manifestations in EVD survivors include a spectrum of disease ranging from anterior uveitis to panuveitis, which confers a high risk of vision impairment and blindness, particularly given the access and resource limitations for ophthalmic subspecialty care in West Africa. Clinical studies in EVD survivors, animal models of EVD and translational investigation, have provided early insight into eye disease pathogenesis. Specifically, ocular inflammation recently observed in EVD survivors is thought to involve direct viral infection, inflammation, and tissue edema. Future research is needed to understand the timing of uveitis onset and management strategies, including the role of antiviral and anti-inflammatory therapies.
在 2014 年至 2016 年国际埃博拉病毒病（EVD）爆发之后，成千上万的 EVD 幸存者面临眼部表现以及全身后遗症的风险，包括关节痛、腹痛、社会心理压力源以及病毒在免疫特权器官中持续存在的风险。EVD 幸存者的眼部表现包括从前葡萄膜炎到全葡萄膜炎的一系列疾病，这会导致视力损害和失明的高风险，特别是在西非获得眼科亚专业护理和资源有限的情况下。EVD 幸存者的临床研究、EVD 动物模型和转化研究为眼部疾病发病机制提供了早期的见解。具体来说，最近在 EVD 幸存者中观察到的眼部炎症被认为涉及直接的病毒感染、炎症和组织水肿。未来需要研究来了解葡萄膜炎发病的时间和管理策略，包括抗病毒和抗炎治疗的作用。
