双向电流 CMOS 恒电位仪用于快速扫描循环伏安法探测器阵列。
A Bidirectional-Current CMOS Potentiostat for Fast-Scan Cyclic Voltammetry Detector Arrays.
出版信息
IEEE Trans Biomed Circuits Syst. 2018 Aug;12(4):894-903. doi: 10.1109/TBCAS.2018.2828828. Epub 2018 May 15.
Abstract
A potentiostat circuit for the application of bipolar electrode voltages and detection of bidirectional currents using a microelectrode array is presented. The potentiostat operates as a regulated-cascode amplifier for positive input currents, and as an active-input regulated-cascode mirror for negative input currents. This topology enables constant-potential amperometry and fast-scan cyclic voltammetry (FSCV) at microelectrode arrays for parallel recording of quantal release events, electrode impedance characterization, and high-throughput drug screening. A 64-channel FSCV detector array, fabricated in a 0.5-$\mu$m, 5-V CMOS process, is also demonstrated. Each detector occupies an area of 45 $\mu$m $\times$ 30 $\mu$m and consists of only 14 transistors and a 50-fF integrating capacitor. The system was validated using prerecorded input stimuli from actual FSCV measurements at a carbon-fiber microelectrode.
摘要
提出了一种用于施加双极电极电压和使用微电极阵列检测双向电流的恒电位仪电路。该恒电位仪作为正输入电流的调节共源共栅放大器，以及作为负输入电流的有源输入调节共源共栅镜工作。这种拓扑结构能够在微电极阵列上进行恒电位安培法和快速扫描循环伏安法（FSCV），用于平行记录量子释放事件、电极阻抗特性和高通量药物筛选。还展示了一个 64 通道的 FSCV 探测器阵列，该阵列采用 0.5-$\mu$m、5-V CMOS 工艺制造。每个探测器的面积为 45 $\mu$m $\times$ 30 $\mu$m，仅由 14 个晶体管和一个 50-fF 积分电容器组成。该系统使用实际 FSCV 测量在碳纤维微电极上的预记录输入刺激进行了验证。
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