Silva Letycia Vieira, Araújo Lúcio Borges de, Azevedo Vivian Mara Gonçalves de Oliveira
Residência Multiprofissional e em Área Profissional da Saúde, Hospital de Clínicas, Faculdade de Medicina, Universidade Federal de Uberlândia - Uberlândia (MG), Brasil.
Faculdade de Matemática, Universidade Federal de Uberlândia - Uberlândia (MG), Brasil.
Rev Bras Ter Intensiva. 2018 Apr-Jun;30(2):174-180. doi: 10.5935/0103-507X.20180023.
To compare the neuropsychomotor development in the first year of life of premature infants with and without bronchopulmonary dysplasia.
A cross-sectional retrospective study was conducted between January 1, 2014, and December 30, 2015, with premature infants weighing < 1,500g at birth and diagnosed with bronchopulmonary dysplasia at the corrected ages of 6 and 9 months, assessed using the DENVER II Developmental Screening Test. Quantitative variables were described as the means, medians and standard deviations. Variables with normal distribution were tested using Student's t test; otherwise, the Mann-Whitney test was used, considering significance at p-value < 0.05. Qualitative variables were expressed as frequencies and percentages. Logistic regression was used with odds ratio analysis to evaluate the effects of other variables as risk factors for changes in neuropsychomotor development.
Infants with bronchopulmonary dysplasia showed greater developmental delay compared with those without bronchopulmonary dysplasia (p-value = 0.001). The factors associated with a higher incidence of changes in neuropsychomotor development, in addition to bronchopulmonary dysplasia, were antenatal steroid, gender, birth weight, 5-minute Apgar score, Score for Neonatal Acute Physiology-Perinatal Extension, duration of oxygen therapy, duration of mechanical ventilation and length of hospital stay. Other variables may also have influenced the result, such as drug use by mothers of infants with bronchopulmonary dysplasia.
Bronchopulmonary dysplasia associated with other pre- and postnatal factors may be considered a risk factor for delayed neuropsychomotor development in the first year of life in premature infants born weighing less than 1,500g.
比较有和没有支气管肺发育不良的早产儿出生后第一年的神经心理运动发育情况。
于2014年1月1日至2015年12月30日进行了一项横断面回顾性研究，纳入出生体重<1500g且在矫正年龄6个月和9个月时被诊断为支气管肺发育不良的早产儿，使用丹佛发育筛查测验（DENVER II）进行评估。定量变量用均值、中位数和标准差描述。呈正态分布的变量采用学生t检验；否则，采用曼-惠特尼检验，以p值<0.05为有统计学意义。定性变量用频率和百分比表示。采用逻辑回归及比值比分析来评估其他变量作为神经心理运动发育变化危险因素的作用。
与没有支气管肺发育不良的婴儿相比，患有支气管肺发育不良的婴儿发育延迟更明显（p值=0.001）。除支气管肺发育不良外，与神经心理运动发育变化发生率较高相关的因素有产前使用类固醇、性别、出生体重、5分钟阿氏评分、新生儿急性生理学围产期扩展评分、氧疗持续时间、机械通气持续时间和住院时间。其他变量也可能影响了结果，如患有支气管肺发育不良婴儿的母亲用药情况。
支气管肺发育不良与其他产前和产后因素相关，可被视为出生体重小于1500g的早产儿出生后第一年神经心理运动发育延迟的一个危险因素。
