2015年，巴西伯南布哥州累西腓大都市区，吉兰-巴雷综合征暴发，可能与先前感染寨卡病毒有关。
Outbreak of Guillain-Barré syndrome possibly related to prior Zika virus infection, Metropolitan Region of Recife, Pernambuco, Brazil, 2015.
作者信息
Nóbrega Martha Elizabeth Brasil da, Araújo Emerson Luiz de Lima, Wada Marcelo Yoshito, Leite Priscila Leal E, Dimech George Santiago, Pércio Jadher
机构信息
Ministério da Saúde, Secretaria de Vigilância em Saúde, Programa de Treinamento em Epidemiologia de Campo Aplicada aos Serviços do Sistema Único de Saúde, Brasília, DF, Brasil.
Ministério da Saúde, Secretaria de Vigilância em Saúde, Coordenação-Geral dos Programas de Controle da Malária e das Doenças Transmitidas pelo Aedes, Brasília, DF, Brasil.
出版信息
Epidemiol Serv Saude. 2018 Jun 28;27(2):e2017039. doi: 10.5123/S1679-49742018000200016.
OBJETIVO
to investigate the occurrence of GBS in the Metropolitan Region of Recife, PE, Brazil, 2015.
METHODS
this was a descriptive study using data from the Hospital Information System, National Pharmaceutical Services Management System and interviews; GBS cases were classified according to Brighton criteria and prior infection according to laboratory and clinical criteria.
RESULTS
in 2015, the number of GBS hospitalizations had a threefold increase in comparison to 2014. We investigated 44 confirmed or probable GBS cases, of which 18 had symptoms of Zika infection up to 35 days before the occurrence of GBS, mainly rash; one case was laboratory-confirmed for Zika virus infection and one death was registered.
CONCLUSION
the findings reinforce a possible relationship between GBS and Zika infection, given the absence of increased GBS occurrence in previous dengue epidemic years, absence of chikungunya transmission records, presence of clinical manifestations compatible with infection and a laboratory confirmation.
目的
调查2015年巴西伯南布哥州累西腓大都市区B群链球菌（GBS）的发病情况。
方法
这是一项描述性研究，使用了医院信息系统、国家药品服务管理系统的数据以及访谈资料；GBS病例根据布莱顿标准进行分类，既往感染根据实验室和临床标准进行判定。
结果
2015年，GBS住院病例数与2014年相比增加了两倍。我们调查了44例确诊或疑似GBS病例，其中18例在GBS发病前35天内出现寨卡病毒感染症状，主要为皮疹；1例经实验室确诊为寨卡病毒感染，并有1例死亡记录。
结论
鉴于在既往登革热流行年份GBS发病率未增加、无基孔肯雅热传播记录、存在与感染相符的临床表现以及实验室确诊结果，这些发现进一步证实了GBS与寨卡病毒感染之间可能存在关联。
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