Suranyi-Cadotte B E, Gauthier S, Lafaille F, DeFlores S, Dam T V, Nair N P, Quirion R
Life Sci. 1985 Dec 16;37(24):2305-11. doi: 10.1016/0024-3205(85)90022-0.
Platelet 3H-imipramine binding and serotonin uptake were studied simultaneously in normal subjects and in depressed, parkinsonian and Alzheimer's disease patients to investigate the usefulness of these variables in the diagnosis of depression in the elderly. Whereas Vmax of platelet serotonin uptake was significantly reduced in all patient groups compared to age matched normal subjects, the density of 3H-imipramine binding was reduced in depressed patients only. The lower Bmax values in depressed patients was independent of patient age. These data suggest that platelet 3H-imipramine binding may be a useful laboratory index which discriminates depression from dementia in the elderly.
在正常受试者以及抑郁症患者、帕金森病患者和阿尔茨海默病患者中，同时研究了血小板3H-丙咪嗪结合和5-羟色胺摄取，以探讨这些变量在老年抑郁症诊断中的实用性。与年龄匹配的正常受试者相比，所有患者组的血小板5-羟色胺摄取Vmax均显著降低，而3H-丙咪嗪结合密度仅在抑郁症患者中降低。抑郁症患者较低的Bmax值与患者年龄无关。这些数据表明，血小板3H-丙咪嗪结合可能是一种有用的实验室指标，可用于区分老年抑郁症和痴呆症。
