Murray Erin K I, Murphy Malia S Q, Smith Graeme N, Graham Charles H, Othman Maha
Department of Biomedical and Molecular Sciences, Queen's University.
Department of Obstetrics and Gynaecology, Kingston General Hospital.
Blood Coagul Fibrinolysis. 2018 Sep;29(6):567-572. doi: 10.1097/MBC.0000000000000759.
: Pregnancy is a state of heightened coagulation, exacerbated in pathological conditions such as preeclampsia. We evaluated the role of thromboelastography (TEG), compared with standard haemostasis tests, in identifying in haemostatic alterations in normotensive pregnancies and pregnancies complicated with preeclampsia. Standard haemostasis tests and TEG were performed on 28 normotensive women and 31 with preeclampsia at delivery, 6 weeks and 6 months postpartum. Results were compared between patient groups, and at different collection times. Standard haemostasis tests failed to reveal consistent differences in haemostatic function between subject groups, mirroring the inconsistency described in the literature. TEG revealed increased coagulability in preeclampsia subjects compared with normotensive subjects at delivery. Haemostatic alterations were normalized by 6 weeks postpartum and remained stable at 6 months postpartum. TEG is superior to standard laboratory haemostatic tests in evaluating antenatal and postpartum haemostatic alterations associated with pregnancy complications such as preeclampsia.
妊娠是一种高凝状态，在子痫前期等病理状况下会加剧。我们评估了血栓弹力图（TEG）与标准止血试验相比，在识别血压正常妊娠和合并子痫前期妊娠的止血改变中的作用。对28名血压正常的女性和31名患有子痫前期的女性在分娩时、产后6周和6个月进行了标准止血试验和TEG检测。对患者组之间以及不同采集时间的结果进行了比较。标准止血试验未能揭示各受试者组之间止血功能的一致差异，这与文献中描述的不一致情况相符。TEG显示，与分娩时血压正常的受试者相比，子痫前期受试者的凝血能力增强。产后6周止血改变恢复正常，产后6个月保持稳定。在评估与子痫前期等妊娠并发症相关的产前和产后止血改变方面，TEG优于标准实验室止血试验。
