多酚亚类与前列腺癌之间的关联：观察性研究的系统评价和荟萃分析

Association between polyphenol subclasses and prostate cancer: a systematic review and meta-analysis of observational studies.

作者信息

Huang Yiping, Wang Wenyan, Jin Jianxiang

机构信息

Department of Urology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China.

School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China.

出版信息

Front Nutr. 2024 Jul 31;11:1428911. doi: 10.3389/fnut.2024.1428911. eCollection 2024.

DOI:10.3389/fnut.2024.1428911

PMID:39144286

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11322767/

Abstract

BACKGROUND

The effect of polyphenol subclasses on prostate cancer (PCA) is controversial. Therefore, the purpose of this study was to investigate the relationship between polyphenol subclasses and PCA incidence.

METHODS

From the establishment of the database to December 2023, a systematic search was conducted on PubMed, Web of Science, Embase, and Cochrane Library to identify relevant observational studies. The adjusted odds ratio (OR) and corresponding 95% confidence interval (95% CI) were used to assess the association.

RESULTS

A total of 38 studies (11 were cohort studies and 27 were case-control studies), composing 824,933 participants, were included in this meta-analysis after excluding irrelevant records. The findings of the study revealed that men who consumed dietary polyphenols had a significantly higher risk of PCA compared to those who never or rarely consumed dietary polyphenols (OR = 1.01, = 0.023), especially dietary flavonol (OR = 1.05, = 0.042), flavanol (OR = 1.03, = 0.026) and anthocyanin (OR = 1.06, = 0.001). Neither total nor subclasses of dietary polyphenols have an effect on non-localized or high-grade PCA (OR = 1.01, = 0.518). Dietary isoflavones tended to reduce the incidence of local or low-grade PCA, although there was no statistically significant difference (OR = 1.00, = 0.081). Regarding serum/plasma polyphenol, total polyphenol (OR = 0.95, = 0.002), genistein (OR = 0.92, = 0.029) and enterolactone (OR = 0.92, = 0.022) can reduce the incidence of PCA. No association was observed between total/subclasses of urinary polyphenols and PCA risk.

CONCLUSION

Polyphenols seem to generally increase the risk of PCA in the male population. The effect of polyphenols on PCA is affected by factors such as polyphenol subclasses, their forms (serum/plasma, urinary, dietary), and PCA-related factors (like PCA stage).

SYSTEMATIC REVIEW REGISTRATION

identifier: CRD42022322699.

摘要

背景

多酚亚类对前列腺癌（PCA）的影响存在争议。因此，本研究旨在探讨多酚亚类与PCA发病率之间的关系。

方法

从数据库建立至2023年12月，在PubMed、Web of Science、Embase和Cochrane图书馆进行系统检索，以识别相关观察性研究。采用调整后的优势比（OR）和相应的95%置信区间（95%CI）来评估关联性。

结果

排除无关记录后，本荟萃分析共纳入38项研究（11项队列研究和27项病例对照研究），涉及824,933名参与者。研究结果显示，与从未或很少食用膳食多酚的男性相比，食用膳食多酚的男性患PCA的风险显著更高（OR = 1.01，P = 0.023），尤其是膳食黄酮醇（OR = 1.05，P = 0.042）、黄烷醇（OR = 1.03，P = 0.026）和花青素（OR = 1.06，P = 0.001）。膳食多酚的总量和亚类均对非局限性或高级别PCA无影响（OR = 1.01，P = 0.518）。膳食异黄酮虽无统计学显著差异，但倾向于降低局限性或低级别PCA的发病率（OR = 1.00，P = 0.081）。关于血清/血浆多酚，总多酚（OR = 0.95，P = 0.002）、染料木黄酮（OR = 0.92，P = 0.029）和肠内酯（OR = 0.92，P = 0.022）可降低PCA的发病率。未观察到尿多酚总量/亚类与PCA风险之间存在关联。