来自光果甘草变种果实的抗炎二萜类化合物

Anti-inflammatory diterpenes from the fruits of L. var. Cham.

作者信息

Fang Shi-Ming, Liu Rui, Li Lin, Yao Jin-Long, Liu Er-Wei, Fan Guan-Wei, Zhang Han, Gao Xiu-Mei

机构信息

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine , Tianjin 300193 , China.

Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine , Tianjin 300193 , China.

出版信息

J Asian Nat Prod Res. 2019 Oct;21(10):985-991. doi: 10.1080/10286020.2018.1482881. Epub 2018 Jul 12.

DOI:10.1080/10286020.2018.1482881

PMID:29996686

Abstract

Two new labdane-type diterpenes, named viterotulin C () and vitexilactone D (), together with five known diterpenes (), were isolated from the fruits of L. var. Cham. Their structures were elucidated by detailed analysis of spectroscopic data. All the compounds were evaluated for their inhibitory effects on nuclear factor-kappa B (NF-κB) pathway in HEK 293 cell line. These compounds presented inhibition on TNF-α-induced NF-κB activation, with inhibition rates ranging from 42.52 ± 10.69% to 68.86 ± 10.76% at the concentration of 50 μM.

摘要

从马鞭草科植物黄荆变种果实中分离得到两个新的半日花烷型二萜，命名为牡荆罗勒素C（）和牡荆内酯D（），以及五个已知的二萜（）。通过对光谱数据的详细分析确定了它们的结构。对所有化合物在人胚肾293细胞系中对核因子-κB（NF-κB）通路的抑制作用进行了评估。这些化合物对肿瘤坏死因子-α（TNF-α）诱导的NF-κB激活具有抑制作用，在50μM浓度下抑制率为42.52±10.69%至68.86±10.76%。