Mottaghipisheh Javad, Kamali Marzie, Doustimotlagh Amir Hossein, Nowroozzadeh Mohammad Hossein, Rasekh Fatemeh, Hashempur Mohammad Hashem, Iraji Aida
Research Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Front Pharmacol. 2024 Mar 21;15:1322083. doi: 10.3389/fphar.2024.1322083. eCollection 2024.
Plants, renowned for their rich reservoir of metabolites, play a pivotal role in addressing health-related issues. The Verbenaceae family stands out, showcasing immense potential in preventing and treating chronic diseases. L. (), a shrub with a rich history in traditional medicine, particularly in Eastern Asia, has garnered attention for its diverse therapeutic applications. This comprehensive review aims to bridge traditional knowledge and contemporary insights by investigating ethnopharmacology, phytochemistry, and pharmacological effects of . The keyword "" and its synonyms were searched within the main scientific databases including PubMed, Web of Science, ScienceDirect, Google Scholar, and Baidu Scholar (from 1974 to 2022, last search: 21.10.2023). Phytochemical analyses reveal a spectrum of secondary metabolites in , including terpenoids, flavonoids, lignans, phytosterols, anthraquinones, and fatty acids. Notably, terpenoids and flavonoids emerge as the main bioactive metabolites. Pharmacological studies validate its therapeutic potential, demonstrating significant antioxidant, anti-inflammatory, hepatoprotective, anticancer, anti-amnesic, antimicrobial, antiviral, anti-malaria, antispasmodic activities, and reported insecticidal effects. Despite existing literature exploring pharmacological attributes and secondary metabolites of related species, a conspicuous gap exists, specifically focusing on the pharmacological activities and novel methods of purification of pure metabolites from . This review aimed to fill this gap by delving into traditional medicinal applications, exploring secondary metabolites comprehensively, and providing an in-depth analysis of pharmacological effects of pure metabolites. Combining traditional uses with contemporary pharmacological insights, this article sought to serve as a crucial reference for future research and practical application of . This approach contributes substantially to understanding the plant, fostering scientific inquiry, and facilitating its broader application in healthcare.
植物以其丰富的代谢产物储备而闻名，在解决与健康相关的问题中发挥着关键作用。马鞭草科尤为突出，在预防和治疗慢性病方面展现出巨大潜力。[植物名称]是一种在传统医学中有着悠久历史的灌木，尤其在东亚地区，因其多样的治疗应用而备受关注。这篇综述旨在通过研究[植物名称]的民族药理学、植物化学和药理作用，将传统知识与当代见解联系起来。在包括PubMed、Web of Science、ScienceDirect、谷歌学术和百度学术在内的主要科学数据库中搜索了关键词“[植物名称]”及其同义词（时间范围为1974年至2022年，最后一次搜索时间：2023年10月21日）。植物化学分析表明[植物名称]中存在一系列次生代谢产物，包括萜类、黄酮类、木脂素、植物甾醇、蒽醌和脂肪酸。值得注意的是，萜类和黄酮类是主要的生物活性代谢产物。药理学研究证实了其治疗潜力，显示出显著的抗氧化、抗炎、保肝、抗癌、抗遗忘、抗菌、抗病毒、抗疟疾、解痉活性以及报道的杀虫作用。尽管现有文献探讨了相关物种的药理特性和次生代谢产物，但仍存在明显差距，特别是在[植物名称]纯代谢产物的药理活性和新型纯化方法方面。本综述旨在通过深入研究传统药用应用、全面探索次生代谢产物以及深入分析纯代谢产物的药理作用来填补这一空白。将传统用途与当代药理学见解相结合，本文旨在为[植物名称]的未来研究和实际应用提供重要参考。这种方法对于理解该植物、促进科学探究以及推动其在医疗保健中的更广泛应用具有重要意义。
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