National Research Council (CNR), Institute of Electronic, Computer and Telecommunications (IEIIT), via de Marini 6, 16149 Genoa, Italy.
National Research Council (CNR), Institute of Science and Technology for Ceramics (ISTEC), Faenza, Italy.
J R Soc Interface. 2018 Jul;15(144). doi: 10.1098/rsif.2018.0236.
Alternative drug delivery approaches to treat cardiovascular diseases are currently under intense investigation. In this domain, the possibility to target the heart and tailor the amount of drug dose by using a combination of magnetic nanoparticles (NPs) and electromagnetic devices is a fascinating approach. Here, an electromagnetic device based on Helmholtz coils was generated for the application of low-frequency magnetic stimulations to manage drug release from biocompatible superparamagnetic Fe-hydroxyapatite NPs (FeHAs). Integrated with a fluidic circuit mimicking the flow of the cardiovascular environment, the device was efficient to trigger the release of a model drug (ibuprofen) from FeHAs as a function of the applied frequencies. Furthermore, the biological effects on the cardiac system of the identified electromagnetic exposure were assessed and by acute stimulation of isolated adult cardiomyocytes and in an animal model. The cardio-compatibility of FeHAs was also assessed and in an animal model. No alterations of cardiac electrophysiological properties were observed in both cases, providing the evidence that the combination of low-frequency magnetic stimulations and FeHAs might represent a promising strategy for controlled drug delivery to the failing heart.
目前，人们正在深入研究替代药物输送方法来治疗心血管疾病。在该领域中，通过使用磁性纳米颗粒 (NPs) 和电磁设备的组合来靶向心脏并调整药物剂量的可能性是一种很有吸引力的方法。在这里，我们基于亥姆霍兹线圈生成了一种电磁设备，用于对生物相容性超顺磁 Fe-羟基磷灰石 NPs (FeHAs) 进行低频磁刺激，以控制药物释放。该设备与模拟心血管环境流动的流体回路集成在一起，可以根据施加的频率有效地触发模型药物（布洛芬）从 FeHAs 中的释放。此外，我们还评估了电磁暴露对心脏系统的生物学影响，包括对分离的成年心肌细胞和动物模型的急性刺激。我们还在动物模型中评估了 FeHAs 的心脏相容性。在这两种情况下，均未观察到心脏电生理特性的改变，这为低频磁刺激与 FeHAs 的结合可能为心力衰竭的药物控制释放提供了一种有前途的策略提供了证据。
