使用美泊利单抗治疗特发性嗜酸性粒细胞增多综合征中的发音障碍和呼吸困难。
Dysphonia and dyspnea in idiopathic hypereosinophilic syndrome treated with Mepolizumab.
作者信息
Kay Dana, Ataya Ali, Liu Xiuli, Auerbach Jena, Urbine Dan
机构信息
Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, Gainesville, FL, USA.
Department of Pathology, University of Florida, Gainesville, FL, USA.
出版信息
Respir Med Case Rep. 2018 May 19;25:30-32. doi: 10.1016/j.rmcr.2018.05.013. eCollection 2018.
Hypereosinophilic syndrome (HES) is characterized by a persistently elevated eosinophil count associated with eosinophil-related end-organ damage and thromboembolic events, in the absence of an identifiable cause. We present a case of idiopathic HES with evidence of peripheral and tissue eosinophilia while on high dose prednisone, associated with muscle tension dysphonia, colitis, and jackhammer esophagus. The patient was treated with the interleukin-5 inhibitor, Mepolizumab, with resolution of symptoms including dyspnea, diarrhea and dysphonia.
高嗜酸性粒细胞综合征（HES）的特征是在没有可识别病因的情况下，嗜酸性粒细胞计数持续升高，并伴有嗜酸性粒细胞相关的终末器官损伤和血栓栓塞事件。我们报告一例特发性HES病例，该患者在服用高剂量泼尼松时出现外周血和组织嗜酸性粒细胞增多的证据，并伴有肌肉紧张性发音障碍、结肠炎和胡桃夹食管。患者接受白细胞介素-5抑制剂美泊利单抗治疗后，呼吸困难、腹泻和发音障碍等症状得到缓解。
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