Femicare vzw, Tienen, Belgium.
Institute of Biotechnology Department of Biothermodynamics and Drug Design, Vilnius University, Vilnius, Lithuania.
Mycoses. 2018 Nov;61(11):857-860. doi: 10.1111/myc.12825. Epub 2018 Aug 1.
This study analyses a relation between sexual habits and the presence of Candida in extra-genital locations as well as a potential effect on therapy response.
Candida cultures were obtained from mouth, nose, anus, urine and perineum of 117 women enrolled in a RVVC treatment trial (ReCiDiF). Sexual behaviour and carriage rates of extra-genital Candida of women responding well to treatment were compared to that of non-responders.
Most respondents were heterosexual. All but one practiced vaginal sex. Regular receptive oral sex was not related to multiple site colonisation with Candida (OR = 1.27; CI95% 0.36-4.48), nor to non-response to therapy (OR = 1.3; CI 95% 0.41-4.73). Also, masturbation was not related to response to therapy (OR 0.8; CI95% 0.31-1.84), nor was anal sex (OR = 0.54; CI95% 0.11-2.72).
Neither oral nor casual anal sex, nor masturbation can be held responsible for the association of the multiple site/anal colonisation with Candida and inferior response to fluconazole maintenance therapy. Changing sexual behaviour during fluconazole maintenance treatment for RVVC in otherwise healthy women should not be advocated. Also, treatment of asymptomatic sexual partners of women with RVVC is not recommended.
本研究分析了性行为习惯与外生殖器部位念珠菌定植的关系，以及对治疗反应的潜在影响。
从参加 RVVC 治疗试验（ReCiDiF）的 117 名女性的口腔、鼻腔、肛门、尿液和会阴部位获取念珠菌培养物。比较对治疗反应良好的女性与反应不佳的女性的性行为和外生殖器念珠菌携带率。
大多数受访者为异性恋。所有人都进行阴道性行为，除了一个人。规律的接受性口交与多部位念珠菌定植（OR=1.27；95%CI 0.36-4.48）或对治疗无反应（OR=1.3；95%CI 0.41-4.73）无关。此外，自慰与治疗反应无关（OR 0.8；95%CI 0.31-1.84），肛交也无关（OR=0.54；95%CI 0.11-2.72）。
无论是口腔性行为还是偶然的肛交，还是自慰，都不能为外生殖器/肛门部位的念珠菌定植与氟康唑维持治疗反应不佳之间的关联负责。在 otherwise healthy 女性中，不应该提倡在氟康唑维持治疗 RVVC 期间改变性行为。此外，也不建议治疗 RVVC 女性的无症状性伴侣。
