Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy.[1] It might be possible to breastfeed safely during intermittent therapy with an appropriate period of breastfeeding abstinence. some have suggested a period of 24 hours before resuming nursing,[2] although the manufacturer recommends an abstinence period of 2 weeks. Capecitabine is metabolized to fluorouracil. Limited information indicates that a maternal continuous intravenous fluorouracil infusion at a dose of 200 mg/square meter daily produces undetectable levels in milk. If capecitabine use is undertaken, monitoring of the infant's complete blood count and differential is advisable. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[3] Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.[4]
大多数资料认为，母亲接受抗肿瘤药物治疗期间禁忌母乳喂养。[1] 在间歇治疗期间，若有适当的母乳喂养禁期，或许有可能安全地进行母乳喂养。一些人建议在恢复哺乳前禁哺24小时，[2] 尽管制造商建议禁哺期为2周。卡培他滨可代谢为氟尿嘧啶。有限的信息表明，母亲每日以200 mg/平方米的剂量持续静脉输注氟尿嘧啶时，乳汁中检测不到该药物。如果使用卡培他滨，建议监测婴儿的全血细胞计数及分类。化疗可能会对母乳的正常微生物群和化学组成产生不利影响。[3] 在孕期接受化疗的女性更有可能在母乳喂养婴儿时遇到困难。[4]
