Topdagi Omer, Timuroglu Aysu
Department of Internal Medicine, Atatürk University School of Medicine, Erzurum, Turkey.
Department of Internal Medicine, Erzincan University School of Medicine, Erzincan, Turkey.
Eurasian J Med. 2018 Jun;50(2):96-98. doi: 10.5152/eurasianjmed.2018.17093. Epub 2018 Jun 1.
We aimed to examine the relationship between carcinoembryonic antigen (CEA) levels in the preoperative period and TNM (T: primary tumor, N: lymph node, M: distant metastasis or metastasis) staging in patients with colorectal cancer in our region.
In the present study, 752 cases diagnosed with colorectal cancer between January 1992 and December 2010 we analyzed retrospectively.
Data of 752 patients diagnosed with colorectal cancer between 1992 and 2010 were evaluated; of the 752 patients, 427 (56.8%) were males and 325 (43.2%) were females with the mean age of 56.8±14.9 years. CEA levels of 316 cases were measured; 52.2% of the samples were within normal limits. Cases with CEA ≤5 ng/mL were majorly in Stage III, whereas those with CEA >5 ng/mL were predominantly in Stage IV. The TNM stage, tumor diameter, and differentiation levels were defined, and no statistically significant relationship was detected between these parameters and CEA levels.
While the CEA levels of 52.2% of participating cases were within normal limits, there was no statistically significant relationship between the CEA levels and differentiation level of tumor, tumor diameter, and TNM staging. According to the data, CEA levels may be within normal limits in the majority of patients with colorectal cancer. Therefore, normal levels of CEA will not rule out colorectal cancer diagnosis, and it can be concluded that these patients should be investigated in detail.
我们旨在研究本地区结直肠癌患者术前癌胚抗原（CEA）水平与TNM（T：原发肿瘤，N：淋巴结，M：远处转移或转移）分期之间的关系。
在本研究中，我们回顾性分析了1992年1月至2010年12月期间诊断为结直肠癌的752例病例。
对1992年至2010年间诊断为结直肠癌的752例患者的数据进行了评估；在这752例患者中，男性427例（56.8%），女性325例（43.2%），平均年龄为56.8±14.9岁。测量了316例患者的CEA水平；52.2%的样本在正常范围内。CEA≤5 ng/mL的病例主要处于III期，而CEA>5 ng/mL的病例主要处于IV期。定义了TNM分期、肿瘤直径和分化程度，未发现这些参数与CEA水平之间存在统计学上的显著关系。
虽然52.2%的参与病例的CEA水平在正常范围内，但CEA水平与肿瘤分化程度、肿瘤直径和TNM分期之间没有统计学上的显著关系。根据数据，大多数结直肠癌患者的CEA水平可能在正常范围内。因此，CEA水平正常并不能排除结直肠癌的诊断，可以得出结论，应对这些患者进行详细检查。
