Immunosuppression with Antitumour Necrosis Factor Therapy Leading to Hyperinfection Syndrome.

is an endemic parasitic infection that can remain asymptomatic for years, but it can cause death in immunosuppressed individuals. Here, we present a case of hyperinfection in a 75-year-old male secondary to sepsis and chronic immunosuppression due to TNF- inhibitors. Despite aggressive treatment including broad-spectrum antibiotics and antihelminths, his respiratory failure worsened and he died after palliative extubation. infection remains a diagnostic challenge. Presentation with is often nonspecific, and eosinophilia is absent in hyperinfection. Diagnosis can be delayed, especially in low-prevalence areas where suspicion is low. should be considered in the differential diagnosis in the presence of risk factors including immunosuppressive therapy, and a travel history should be carefully obtained. Patients with recurrent enterobacterial sepsis or respiratory failure with diffuse infiltrates in the setting of eosinophilia should undergo testing for . A multidisciplinary approach can result in earlier diagnosis and favorable outcomes.