Sasano Hiroyuki, Obana Akira, Sharifzadeh Mohsen, Bernstein Paul S, Okazaki Shigetoshi, Gohto Yuko, Seto Takahiko, Gellermann Werner
Department of Ophthalmology, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan.
Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan.
Transl Vis Sci Technol. 2018 Jul 9;7(4):3. doi: 10.1167/tvst.7.4.3. eCollection 2018 Jul.
To demonstrate the presence of macular pigment in the retina of premature infants, and to examine its changes with age.
The participants included 40 premature infants. Infants who had received laser photocoagulation for retinopathy of prematurity were excluded. Macular pigment optical density (MPOD) was measured by fundus reflectometry using RetCam3, a digital fundus camera. The reflection imaging was performed for ROP screening. The imaging time points were from a post menstrual age (PMA) of 29 weeks 0 days to 46 weeks 5 days.
The MPOD levels could be obtained from 39 premature infants. The levels at the first measurement ranged from 0 to 0.18 (mean 0.076, SD 0.044). The earliest time, when a nonvanishing MPOD level was obtained, was at a PMA of 33 weeks and 2 days, and that level was 0.05. The initial examination MPOD levels showed a moderate correlation with age ( = 0.32, < 0.00017). The mean MPOD levels measured each week during the follow-up period showed a very strong correlation with age ( = 0.91, < 0.0001). A regression line of MPOD = 0.0069 × age - 0.1783 was derived, where age is counted in PMA days.
The MPOD levels of premature infants were for the first time measured in living eyes. Macular pigment increased linearly with age.
Macular pigment increased with the development of macular morphology. This result suggested the importance of nutritional management of infants and mothers during perinatal period.
证明早产儿视网膜中黄斑色素的存在，并研究其随年龄的变化。
研究对象包括40名早产儿。接受过早产儿视网膜病变激光光凝治疗的婴儿被排除。使用数字眼底相机RetCam3通过眼底反射ometry测量黄斑色素光密度（MPOD）。进行反射成像以筛查视网膜病变。成像时间点为孕龄（PMA）29周0天至46周5天。
可从39名早产儿获得MPOD水平。首次测量时的水平范围为0至0.18（平均0.076，标准差0.044）。获得非零MPOD水平的最早时间是在孕龄33周2天，该水平为0.05。初始检查时的MPOD水平与年龄呈中度相关（= 0.32，<0.00017）。随访期间每周测量的平均MPOD水平与年龄呈非常强的相关性（= 0.91，<0.0001）。得出MPOD = 0.0069×年龄 - 0.1783的回归线，其中年龄以孕龄天数计算。
首次在活眼中测量了早产儿的MPOD水平。黄斑色素随年龄呈线性增加。
黄斑色素随黄斑形态的发育而增加。这一结果提示围产期婴儿和母亲营养管理的重要性。
