Yamaga Iku, Kawaguchi-Sakita Nobuko, Asao Yasufumi, Matsumoto Yoshiaki, Yoshikawa Aya, Fukui Toshifumi, Takada Masahiro, Kataoka Masako, Kawashima Masahiro, Fakhrejahani Elham, Kanao Shotaro, Nakayama Yoshie, Tokiwa Mariko, Torii Masae, Yagi Takayuki, Sakurai Takaki, Haga Hironori, Togashi Kaori, Shiina Tsuyoshi, Toi Masakazu
Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Japan.
Department of Clinical Oncology, Kyoto University Hospital, Japan.
Photoacoustics. 2018 Jun 20;11:6-13. doi: 10.1016/j.pacs.2018.06.002. eCollection 2018 Sep.
This study aimed to identify the characteristics of the vascular network in the superficial subcutaneous layer of the breast and to analyze differences between breasts with cancer and contralateral unaffected breasts using vessel branching points (VBPs) detected by three-dimensional photoacoustic imaging with a hemispherical detector array. In 22 patients with unilateral breast cancer, the average VBP counts to a depth of 7 mm below the skin surface were significantly greater in breasts with cancer than in the contralateral unaffected breasts (p < 0.01). The ratio of the VBP count in the breasts with cancer to that in the contralateral breasts was significantly increased in patients with a high histologic grade (p = 0.03), those with estrogen receptor-negative disease (p < 0.01), and those with highly proliferative disease (p < 0.01). These preliminary findings indicate that a higher number of VBPs in the superficial subcutaneous layer of the breast might be a biomarker for primary breast cancer.
本研究旨在利用半球形探测器阵列的三维光声成像检测的血管分支点（VBP），确定乳腺浅表皮下层血管网络的特征，并分析患癌乳房与对侧未受影响乳房之间的差异。在22例单侧乳腺癌患者中，癌侧乳房皮肤表面以下7毫米深度处的平均VBP计数显著高于对侧未受影响的乳房（p<0.01）。组织学分级高的患者（p=0.03）、雌激素受体阴性疾病患者（p<0.01）和增殖性高的疾病患者（p<0.01），癌侧乳房与对侧乳房的VBP计数之比显著增加。这些初步研究结果表明，乳腺浅表皮下层中较高数量的VBP可能是原发性乳腺癌的生物标志物。
