University of Cordoba, Tropical Biological Research, Monteria, Cordoba, Colombia.
The Reference Laboratory of Spirochetes, Institute of Tropical Medicine "Pedro Kourí", Cuba.
Biomed Res Int. 2018 May 29;2018:6473851. doi: 10.1155/2018/6473851. eCollection 2018.
To describe and analyze the clinical and epidemiological status in 28 confirmed cases of human leptospirosis at the main public hospital of Cordoba.
Between 2012 and 2013, we conducted an active surveillance at the main hospital of Cordoba to establish the etiologic diagnosis of the undifferentiated tropical febrile illness (UTFI) cases. UTFI is defined as a fever without an infection focus in the initial physical examination or in basic laboratory tests. Patients in acute phase were accompanied by prodromal symptoms, including myalgia, arthralgia, headache, asthenia, chills, icterus, dyspnea, abdominal pain, rash, and nausea. Samples were collected on admission and at discharge. Clinical and epidemiological data were collected for each patient. Microscopic agglutination test (MAT) was performed.
The 28 leptospirosis cases presented the following gender distribution: male (n=24) and female (n=4). The duration of hospitalization was 10.39 days. The main symptoms and clinical manifestations were fever, headache and nausea, vomiting, and abdominal pain, all of which occurred in up to 60% of patients. Of the 28 cases studied, 4 were fatal. The most frequent infecting serogroups were Ballum and Canicola.
Leptospirosis is a common cause of undifferentiated tropical febrile illness in Colombia; it is important to establish ongoing and accurate surveillance for acute febrile illness to facilitate the detection of cases of leptospirosis.
描述和分析科尔多瓦主要公立医院 28 例确诊人类钩端螺旋体病的临床和流行病学状况。
在 2012 年至 2013 年期间，我们在科尔多瓦主要医院进行了主动监测，以确定未分化热带发热病（UTFI）病例的病因诊断。UTFI 定义为在初始体检或基本实验室检查中无感染焦点的发热。急性期患者伴有前驱症状，包括肌痛、关节痛、头痛、乏力、寒战、黄疸、呼吸困难、腹痛、皮疹和恶心。入院时和出院时采集样本。为每位患者收集临床和流行病学数据。进行显微镜凝集试验（MAT）。
28 例钩端螺旋体病患者的性别分布如下：男性（n=24）和女性（n=4）。住院时间为 10.39 天。主要症状和临床表现为发热、头痛和恶心、呕吐和腹痛，这些症状在多达 60%的患者中出现。在研究的 28 例病例中，有 4 例死亡。最常见的感染血清群是鲍尔姆和坎尼考拉。
钩端螺旋体病是哥伦比亚未分化热带发热病的常见病因；对急性发热病进行持续和准确的监测以发现钩端螺旋体病病例非常重要。
