Chen Chun-Chieh, Baikoghli Mo A, Cheng R Holland
Department of Molecular & Cellular Biology, University of California, Davis, CA 95616, USA.
Department of Dermatology, University of California, Sacramento, CA 95817, USA.
Pharm Pat Anal. 2021 Jan 20;10(1):13-24. doi: 10.4155/ppa-2020-0034.
The use of nanoparticulate systems to diagnose and treat tumors has gained momentum with the rapid development of nanomedicine. Many nanotheranostics fail due to insufficient bioavailability and low accumulation at the tumor site, resulting in undesirable side effects. We describe the use of an engineered hepatitis E viral nanoparticle (HEVNP) with enhanced bioavailability, tissue retention and mucosal penetration capacities. HEVNP is a modular nanocapsule that can encapsulate heterologous nucleotides, proteins and inorganic metals, such as ferrite oxide nanoparticles. Additionally, the exterior protruding arms of HEVNP is composed of loops that are used for chemical coupling of targeting and therapeutic peptides. We propose the use of HEVNP to target colorectal cancer (i.e., polyps) with imaging-guided delivery using colonoscopy.
随着纳米医学的迅速发展，使用纳米颗粒系统来诊断和治疗肿瘤的研究日益兴起。许多纳米诊疗方法由于生物利用度不足和在肿瘤部位的低蓄积而失败，从而导致不良副作用。我们描述了一种经过工程改造的戊型肝炎病毒纳米颗粒（HEVNP），其具有增强的生物利用度、组织滞留能力和粘膜穿透能力。HEVNP是一种模块化纳米胶囊，可封装异源核苷酸、蛋白质和无机金属，如氧化亚铁纳米颗粒。此外，HEVNP的外部突出臂由环组成，这些环用于靶向和治疗肽的化学偶联。我们建议使用HEVNP通过结肠镜检查进行成像引导递送，以靶向结直肠癌（即息肉）。
