Zhang Qianyu, Li Libo
TCM-integrated Cancer Center, TCM-integrated Hospital, Southern Medical University, 510315 Guangzhou, P.R. China.
J BUON. 2018 May-Jun;23(3):561-567.
Photodynamic therapy (PDT) has attracted widespread attention in recent years as a non-invasive and highly selective approach for cancer treatment. PDT involves the activation of a photosensitizer by an appropriate wavelength of light, generating transient levels of reactive oxygen species (ROS). However, the utilization of PDT against deep tumors has been greatly limited by insufficient luminous flux and the occurrence of peripheral tissue damage. Therefore, experts have begun to explore whether the combination of PDT with other treatments can improve its efficacy. In this review, we have collected articles about experiments (in vitro and in vivo) and clinical research on photodynamic combination therapies in recent years, roughly divided into four parts corresponding to PDT combined with chemotherapy, radiotherapy, immunotherapy and other therapies, to compare the therapeutic effects of the combination therapy and monotherapy. The results showed that photodynamic combination treatments, in general, perform better than single treatment modalities. Thus, the increased therapeutic effects, reduced side effects and coordination treatment effects of PDT are worth of further exploration.
近年来，光动力疗法（PDT）作为一种非侵入性且具有高度选择性的癌症治疗方法，已引起广泛关注。光动力疗法涉及通过适当波长的光激活光敏剂，产生瞬态水平的活性氧（ROS）。然而，由于光通量不足和外周组织损伤的发生，光动力疗法在深部肿瘤治疗中的应用受到了极大限制。因此，专家们已开始探索光动力疗法与其他治疗方法联合使用是否能够提高其疗效。在本综述中，我们收集了近年来有关光动力联合疗法的实验（体外和体内）及临床研究的文章，大致分为与化疗、放疗、免疫疗法及其他疗法联合的光动力疗法四个部分，以比较联合疗法与单一疗法的治疗效果。结果表明，一般而言，光动力联合治疗比单一治疗方式表现更佳。因此，光动力疗法提高的治疗效果、减少的副作用及协同治疗效果值得进一步探索。
