Rodrigues-Costa Fernanda, Cayô Rodrigo, Matos Adriana Pereira, Girardello Raquel, Martins Willames M B S, Carrara-Marroni Floristher Elaine, Gales Ana Cristina
Universidade Federal de São Paulo - UNIFESP, Laboratório Alerta, Disciplina de Infectologia, Departamento de Medicina, Escola Paulista de Medicina - EPM, São Paulo - SP, Brazil.
Universidade Federal de São Paulo - UNIFESP, Laboratório Alerta, Disciplina de Infectologia, Departamento de Medicina, Escola Paulista de Medicina - EPM, São Paulo - SP, Brazil.
Res Microbiol. 2019 Jan-Feb;170(1):53-59. doi: 10.1016/j.resmic.2018.07.001. Epub 2018 Jul 9.
Nine carbapenem-resistant Acinetobacter baumannii isolates carrying bla and an ISAba1 upstream occAB1 were evaluated. They were clonally related and belonged to ST107. An OXA-143-producing A. baumannii ST107 strain (Ac-148) that did not possess ISAba1 upstream occAB1 was included in the analysis. Reduction in the expression of occAB1 and a 4-fold increase of carbapenem MICs were observed for all isolates, except for the Ac-148 strain, probably due to the presence of ISAba1 upstream occAB1 but in the same transcriptional orientation. We reported an A. baumannii ST107 clone carrying bla that acquired a mutation resulting into bla and mobilized ISAba1 upstream occAB1.
对9株携带bla且在occAB1上游存在ISAba1的耐碳青霉烯鲍曼不动杆菌分离株进行了评估。它们具有克隆相关性，属于ST107。分析中纳入了一株不具有ISAba1位于occAB1上游的产OXA-143鲍曼不动杆菌ST107菌株（Ac-148）。除Ac-148菌株外，所有分离株均观察到occAB1表达降低且碳青霉烯类最低抑菌浓度（MIC）增加了4倍，这可能是由于ISAba1位于occAB1上游但转录方向相同。我们报道了一株携带bla的鲍曼不动杆菌ST107克隆，该克隆发生了导致bla的突变，并使ISAba1移动到occAB1上游。
