幽门螺杆菌及其与6至12岁无症状儿童肠道微生物群变化的关系。
Helicobacter pylori and its relationship with variations of gut microbiota in asymptomatic children between 6 and 12 years.
作者信息
Benavides-Ward Araceli, Vasquez-Achaya Fernando, Silva-Caso Wilmer, Aguilar-Luis Miguel Angel, Mazulis Fernando, Urteaga Numan, Del Valle-Mendoza Juana
机构信息
School of Nutrition, Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.
School of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.
出版信息
BMC Res Notes. 2018 Jul 13;11(1):468. doi: 10.1186/s13104-018-3565-5.
OBJECTIVE
To determine the variations in the composition of the intestinal microbiota in asymptomatic children infected with Helicobacter pylori in comparison with children without the infection.
RESULTS
Children infected with H. pylori doubled their probability of presenting 3 of 9 genera of bacteria from the gut microbiota, including: Proteobacteria (p = 0.008), Clostridium (p = 0.040), Firmicutes (p = 0.001) and Prevotella (p = 0.006) in comparison to patients without the infection. We performed a nutritional assessment and found that growth stunting was statistically significantly higher in patients infected with H. pylori (p = 0.046).
目的
确定感染幽门螺杆菌的无症状儿童与未感染儿童相比肠道微生物群组成的变化。
结果
与未感染幽门螺杆菌的儿童相比，感染幽门螺杆菌的儿童肠道微生物群中9个菌属中有3个菌属出现的概率增加了一倍，这3个菌属包括：变形菌门（p = 0.008）、梭菌属（p = 0.040）、厚壁菌门（p = 0.001）和普雷沃菌属（p = 0.006）。我们进行了营养评估，发现感染幽门螺杆菌的患者生长发育迟缓在统计学上显著更高（p = 0.046）。
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