State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu, China.
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Front Cell Infect Microbiol. 2022 Aug 3;12:914418. doi: 10.3389/fcimb.2022.914418. eCollection 2022.
In the human body, each microbial habitat exhibits a different microbial population pattern, and these distinctive microflorae are highly related to the development of diseases. The microbial interactions from host different niches are becoming crucial regulators to shape the microbiota and their physiological or pathological functions. The oral cavity and gut are the most complex and interdependent microbial habitats. is one of the most important pathogens from digestive tract, especially the stomach, due to its direct relationships with many gastric diseases including gastric cancer. infections can destroy the normal gastric environment and make the stomach a livable channel to enhance the microbial interactions between oral cavity and gut, thus reshaping the oral and gut microbiomes. can be also detected in the oral and gut, while the interaction between the oral-gut axis microbiota and plays a major role in 's colonization, infection, and pathogenicity. Both the infection and eradication of and its interaction with oral-gut axis microbiota can alter the balance of the microecology of the oral-gut axis, which can affect the occurrence and progress of related diseases. The shift of oral-gut axis microbiota and their interactions with maybe potential targets for infectious diagnosis and treatment.
在人体中，每个微生物栖息地都表现出不同的微生物种群模式，这些独特的微生物与疾病的发展高度相关。来自宿主不同小生境的微生物相互作用正在成为塑造微生物群及其生理或病理功能的关键调节剂。口腔和肠道是最复杂和相互依存的微生物栖息地。幽门螺杆菌是消化道中最重要的病原体之一，特别是在胃部，因为它与许多胃部疾病（包括胃癌）直接相关。幽门螺杆菌感染可以破坏正常的胃部环境，使胃部成为一个宜居的通道，从而增强口腔和肠道之间的微生物相互作用，从而重塑口腔和肠道微生物组。幽门螺杆菌也可以在口腔和肠道中检测到，而口腔-肠道轴微生物群与幽门螺杆菌之间的相互作用在其定植、感染和致病性中起着重要作用。幽门螺杆菌的感染和根除及其与口腔-肠道轴微生物群的相互作用都可以改变口腔-肠道轴微生态的平衡，这可能会影响相关疾病的发生和进展。口腔-肠道轴微生物群的转移及其与幽门螺杆菌的相互作用可能是幽门螺杆菌感染诊断和治疗的潜在靶点。
