中国广西省醉鱼草属植物中阿朴啡类生物碱。

Aporphine Alkaloids from Illigera aromatica from Guangxi Province, China.

机构信息

Department of Applied Chemistry, School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, PR China.

Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huaian 223003, PR China.

出版信息

Phytochemistry. 2018 Oct;154:73-76. doi: 10.1016/j.phytochem.2018.06.017. Epub 2018 Jul 6.

DOI:10.1016/j.phytochem.2018.06.017

PMID:30006090

Abstract

Three undescribed aporphine alkaloids laurodionine B (1), illigerine A (2), and N-formyl-laurolitsine (3) were isolated from the methanolic extracts of the Chinese medicinal plant, Illigera aromatica, together with three known analogues (4-6). The chemical structures of 1-6 were identified by spectroscopic methods including 1D and 2D NMR (H, C, COSY, HSQC, and HMBC) and high resolution mass spectrometry (HRESIMS). Compounds 1-3 showed moderate inhibitory activities in vitro against two cultured tumor cell lines, Hela and SMMC7721, with IC values of 32.42-62.90 μM. Only compound 1 had in vitro cytotoxic activity against Bcap37 cells, with the IC value of 90.61 μM.

摘要

从中国药用植物白背叶 Illigera aromatica 的甲醇提取物中分离得到了三种未描述的阿朴啡生物碱：laurodionine B（1）、异丽碱 A（2）和 N-甲酰劳洛替辛（3），以及三种已知类似物（4-6）。通过光谱方法，包括 1D 和 2D NMR（H、C、COSY、HSQC 和 HMBC）和高分辨率质谱（HRESIMS），鉴定了 1-6 的化学结构。化合物 1-3 在体外对两种培养的肿瘤细胞系 Hela 和 SMMC7721 显示出中等抑制活性，IC 值为 32.42-62.90 μM。只有化合物 1 对 Bcap37 细胞具有体外细胞毒性活性，IC 值为 90.61 μM。