唐松草甲素，一种从华东唐松草中提取的具有细胞毒性的阿朴啡-苄基异喹啉生物碱。

Thalifaberidine, a cytotoxic aporphine-benzylisoquinoline alkaloid from Thalictrum faberi.

作者信息

Lin L Z, Hu S F, Zaw K, Angerhofer C K, Chai H, Pezzuto J M, Cordell G A, Lin J, Zheng D M

机构信息

Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612.

出版信息

J Nat Prod. 1994 Oct;57(10):1430-6. doi: 10.1021/np50112a013.

DOI:10.1021/np50112a013

PMID:7528786

Abstract

From Thalictrum faberi, thalifaberidine [1], a new aporphine-benzylisoquinoline alkaloid, together with four known alkaloids, thalifaramine [2], thalifaricine [3], thalifarazine [4], and thalifaronine [5], were isolated. Thalifaberidine [1] was identified as 6',8-desmethylthalifaberine, and its 1H- and 13C-nmr data were completely assigned through the use of one- and two-dimensional nmr techniques. Thalifaberidine [1], thalifaberine [6], and thalifasine [7] showed cytotoxic activity against several human cancer cell lines, as well as antimalarial activity.

摘要

从华东唐松草中分离得到了一种新的阿朴啡-苄基异喹啉生物碱——唐松草定碱[1]，以及四种已知生物碱，即唐松草胺[2]、唐松草辛[3]、唐松草嗪[4]和唐松草酮[5]。唐松草定碱[1]被鉴定为6',8-去甲基唐松草碱，通过一维和二维核磁共振技术完全确定了其1H-和13C-核磁共振数据。唐松草定碱[1]、唐松草碱[6]和唐松草新碱[7]对多种人类癌细胞系显示出细胞毒性活性以及抗疟活性。