Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Guilin Medical University, Guilin 541199, PR China.
Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Guilin Medical University, Guilin 541199, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650302, PR China; Guangxi Key Laboratory of Drug Discovery and Optimization, Guilin Medical University, Guilin 541199, PR China.
Fitoterapia. 2024 Jan;172:105737. doi: 10.1016/j.fitote.2023.105737. Epub 2023 Nov 7.
Three undescribed alkaloids (+)-9-hydroxy-N-acetylnordicentrine (1), illigeparvinine (2), and deca-(2E,4Z)-2,4-dienoic acid 4-hydroxy-2-phenethyl amide (3), along with 19 known analogues (4-22), were isolated from the ethnic medicinal plant Illigera parviflora. Their structures were established using NMR, MS, and other spectroscopic analyses as well as X-ray diffraction. Moderate inhibition of human gastric carcinoma (MGC-803) and breast adenocarcinoma (T-47D) cell lines proliferation was observed for actinodaphnine (4) with IC values of 28.74 and 11.65 μM, respectively. These findings contribute new anticancer potential compounds and expand the chemical diversity known from the valuable traditional medicinal plant I. parviflora.
（+）-9-羟基-N-乙酰降乌头碱（1）、异藜芦定碱（2）和癸烯酸-（2E，4Z）-2,4-二烯酸 4-羟基-2-苯乙酰胺（3），以及 19 种已知类似物（4-22）。它们的结构通过 NMR、MS 和其他光谱分析以及 X 射线衍射确定。 actinodaphnine（4）对人胃癌（MGC-803）和乳腺癌（T-47D）细胞系的增殖有中等抑制作用，IC 值分别为 28.74 和 11.65 μM。这些发现为具有抗癌潜力的化合物提供了新的研究方向，并扩展了小花清风藤这一有价值的传统药用植物的化学多样性。
